Publication Name	World Journal of Psychiatry
Manuscript ID	13521
Country	United States

Received	2014-08-26 08:25
Peer-Review Started	2014-08-27 10:22
To Make the First Decision	2014-12-17 11:39
Return for Revision	2014-12-19 09:03
Revised	2015-01-13 00:40
Second Decision	2015-01-28 12:02
Accepted by Journal Editor-in-Chief	2015-01-28 21:58
Accepted by Executive Editor-in-Chief	2015-02-09 09:36
Articles in Press	2015-02-09 09:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-12 18:01
Publish the Manuscript Online	2015-03-23 14:43

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Psychiatry
Manuscript Type	Review
Article Title	Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology
Manuscript Source	Invited Manuscript
All Author List	Robert K McNamara, Jennifer J Vannest and Christina J Valentine
Funding Agency and Grant Number	Funding Agency Grant Number NARSAD, Martek Biosciences Inc Perinatal Institute at Cincinnati Children’s Hospital to Valentine CJ
Corresponding Author	Robert K McNamara, PhD, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, 260 Stetson Street, Cincinnati, OH 45219, United States. robert.mcnamara@uc.edu
Key Words	Omega-3 fatty acids; Brain development; Prefrontal cortex; Docosahexaenoic acid; Connectivity; Attention deficit/hyperactivity disorder; Mood; Cognition; Bipolar disorder; Schizophrenia; Amygdala
Core Tip	Although the role of perinatal brain omega-3 fatty acid (DHA) accrual on the maturation and long-term stability of cortical circuitry is only beginning to be fully understood, extant translational evidence suggests that DHA plays a role in the initial development and early maturation of cortical circuits. Emerging evidence from human neuroimaging studies further suggests that psychiatric disorders that initially emerge in childhood and adolescence and associated with low blood DHA levels are characterized by frontal circuit deficits compared with healthy developing youth. Based on existing evidence, these associations could have significant implications for informing novel early intervention strategies aimed at reducing the transmission of psychopathology.
Publish Date	2015-03-23 14:43
Citation	McNamara RK, Vannest JJ, Valentine CJ. Role of perinatal long-chain omega-3 fatty acids in cortical circuit maturation: Mechanisms and implications for psychopathology. World J Psychiatr 2015; 5(1): 15-34
URL	http://www.wjgnet.com/2220-3206/full/v5/i1/15.htm
DOI	http://dx.doi.org/10.5498/wjp.v5.i1.15

Manuscript File	13521-Review.doc
Answering Reviewers	13521-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13521-Conflict-of-interest statement.pdf
Copyright License Agreement	13521-Copyright assignment.pdf
Peer-review Report	13521-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13521-Journal Editor-in-Chief's review report.pdf
Scientific Misconduct Check	13521-Scientific misconduct check.pdf
Scientific Editor Work List	13521-Scientific editor work list.pdf