| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Aldona Kasprzak, Agnieszka Adamek, Wiesława Przybyszewska, Przemysław Pyda, Jacek Szmeja, Agnieszka Seraszek-Jaros, Agata Lanzafame, Anna Surdacka, Iwona Mozer-Lisewska and Maria Koczorowska |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Minister of Education and Science, Warsaw, Poland |
NN401009437 |
|
| Corresponding Author |
Aldona Kasprzak, MD, PhD, Professor, Department of Histology and Embryology, Poznan University of Medical Sciences, 6 Swiecicki Street, 60-781 Poznan, Poland. akasprza@ump.edu.pl |
| Key Words |
Chronic hepatitis C; Insulin-like growth factor-1 receptor; Insulin-like growth factor-1 mRNA isoforms; Quantitative polymerase chain reaction |
| Core Tip |
Hepatitis C virus (HCV) may induce alteration of insulin-like growth factor (IGF)-1 splicing profile. A quantitative polymerase chain reaction analysis confirmed higher relative expression of total IGF-1 mRNA and of IGF-1 mRNAs isoforms P1, A, and C in HCV-infected livers as compared to the control. An increase in inflammatory activity (grading) of HCV-infected livers was linked to decreased IGF-1 mRNA expression, an altered profile of mRNA isoforms, and to an increase in IGF-1R mRNA expression. Decreased expression level of IGF-1 mRNA isoforms and an increased liver expression of IGF-1R mRNA were associated with indicators of liver damage (e.g., grading, staging, steatosis, and liver serum enzyme activity), and may be of prognostic significance. |
| Publish Date |
2015-04-07 17:13 |
| Citation |
Kasprzak A, Adamek A, Przybyszewska W, Pyda P, Szmeja J, Seraszek-Jaros A, Lanzafame A, Surdacka A, Mozer-Lisewska I, Koczorowska M. Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C. World J Gastroenterol 2015; 21(13): 3867-3875 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i13/3867.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i13.3867 |
