Publication Name	World Journal of Methodology
Manuscript ID	13537
Country	United States

Received	2014-08-27 09:00
Peer-Review Started	2014-08-27 14:07
To Make the First Decision	2014-11-27 12:24
Return for Revision	2014-12-02 15:36
Revised	2015-01-09 00:00
Second Decision	2015-01-28 12:02
Accepted by Journal Editor-in-Chief	2015-01-28 17:30
Accepted by Executive Editor-in-Chief	2015-04-20 14:15
Articles in Press	2015-04-20 14:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-11 19:08
Publish the Manuscript Online	2015-07-07 20:52

ISSN	2222-0682 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Toxicology
Manuscript Type	Review
Article Title	Past, present and future of cyanide antagonism research: From the early remedies to the current therapies
Manuscript Source	Invited Manuscript
All Author List	Ilona Petrikovics, Marianna Budai, Kristof Kovacs and David E Thompson
Funding Agency and Grant Number	Funding Agency Grant Number Robert A. Welch Foundation at Sam Houston State University x-0011
Corresponding Author	Ilona Petrikovics, PhD, Department of Chemistry, Sam Houston State University, 1806 Avenue J, Huntsville, TX 77341, United States. ixp004@shsu.edu
Key Words	Cyanide; Hydrocyanic acid; Antagonist; Antidote; Cobinamide; Sulfanegen; Sulfane sulfur donor
Core Tip	This paper reviews milestones in antidotal therapies for cyanide (CN) spanning early history, current antidotal systems, and research towards next generation therapies. Presently used CN therapies include: methemoglobin/nitric oxide generators (e.g., sodium nitrite, amyl nitrite, and dimethyl aminophenol), sulfur donors (e.g., sodium thiosulfate and glutathione), and direct binding agents (e.g., hydroxocobalamin and dicobalt edetate). New antidotes, formulations, and delivery systems are presently being developed for rapid administration at the point of intoxication in mass casualty scenarios. These hold promise for a new generation of improved CN countermeasures.
Publish Date	2015-07-07 20:52
Citation	Petrikovics I, Budai M, Kovacs K, Thompson DE. Past, present and future of cyanide antagonism research: From the early remedies to the current therapies. World J Methodol 2015; 5(2): 88-100
URL	http://www.wjgnet.com/2222-0682/full/v5/i2/88.htm
DOI	http://dx.doi.org/10.5662/wjm.v5.i2.88

Full Article (PDF)	WJM-5-88.pdf
Full Article (Word)	WJM-5-88.doc
Manuscript File	13537-Review.doc
Answering Reviewers	13537-Answering reviewers.pdf
Audio Core Tip	13537-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	13537-Conflict-of-interest statement.pdf
Copyright License Agreement	13537-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140826201750.doc
Peer-review Report	13537-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13537-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13537-Scientific misconduct check.pdf
Scientific Editor Work List	13537-Scientific editor work list.pdf