Publication Name	World Journal of Hepatology
Manuscript ID	13539
Country	Japan

Received	2014-08-27 08:56
Peer-Review Started	2014-08-27 14:18
To Make the First Decision	2014-09-16 10:54
Return for Revision	2014-09-19 16:34
Revised	2014-10-03 21:20
Second Decision	2014-10-27 16:57
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-27 17:16
Articles in Press	2014-10-27 17:16
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-08 17:56
Publish the Manuscript Online	2014-12-13 17:50

ISSN	1948-5182 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Food Science & Technology
Manuscript Type	Topic Highlights
Article Title	Functional foods effective for hepatitis C: Identification of oligomeric proanthocyanidin and its action mechanism
Manuscript Source	Invited Manuscript
All Author List	Yo-ichi Ishida, Masahiko Takeshita and Hiroaki Kataoka
Funding Agency and Grant Number	Funding Agency Grant Number Japan Science and Technology Agency
Corresponding Author	Hiroaki Kataoka, MD, PhD, Professor, Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. mejina@med.miyazaki-u.ac.jp
Key Words	Hepatitis C virus; Blueberry leaves; Functional foods; Oligomeric proanthocyanidin; Heterogeneous nuclear ribonucleoproteins
Core Tip	An infection by hepatitis C virus (HCV) causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. While the combination of pegylated α-interferon and ribavirin is used for the elimination of HCV, a new anti-HCV drug is required due to the poor efficacy and serious side-effects associated with this combination therapy. We searched for new anti-HCV agents from natural products and then identified oligomeric proanthocyanidin from blueberry leaves. Further investigations suggested that several heterogeneous nuclear ribonucleoproteins may be the candidate proteins involved in the proanthocyanidin-mediated inhibition of HCV subgenomic expression. Oligomeric proanthocyanidin isolated from blueberry leaves may have potential usefulness as an anti-HCV compound.
Publish Date	2014-12-13 17:50
Citation	Ishida Y, Takeshita M, Kataoka H. Functional foods effective for hepatitis C: Identification of oligomeric proanthocyanidin and its action mechanism. World J Hepatol 2014; 6(12): 870-879
URL	http://www.wjgnet.com/1948-5182/full/v6/i12/870.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i12.870

Full Article (PDF)	WJH-6-870.pdf
Full Article (Word)	WJH-6-870.doc
Manuscript File	13539-Review.doc
Answering Reviewers	13539-Answering reviewers.pdf
Copyright License Agreement	13539-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20140826214409.pdf
Peer-review Report	13539-Peer review(s).pdf
Scientific Misconduct Check	13539-CrossCheck.jpg
Scientific Editor Work List	13539-Scientific editor work list.pdf