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7/10/2015 6:24:00 PM | Browse: 1021 | Download: 952
Publication Name World Journal of Diabetes
Manuscript ID 13560
Country/Territory Australia
Received
2014-08-27 17:06
Peer-Review Started
2014-08-28 16:29
To Make the First Decision
2014-12-17 11:20
Return for Revision
2014-12-19 12:10
Revised
2014-12-30 12:54
Second Decision
2015-02-27 09:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-03-09 16:50
Articles in Press
2015-03-09 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-27 16:15
Publish the Manuscript Online
2015-07-10 18:24
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Physiology
Manuscript Type Review
Article Title Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy
Manuscript Source Invited Manuscript
All Author List Mark T Waddingham, Amanda J Edgley, Hirotsugu Tsuchimochi, Darren J Kelly, Mikiyasu Shirai and James T Pearson
Funding Agency and Grant Number
Funding Agency Grant Number
International Synchrotron Access Program (AS/IA133) of the Australian Synchrotron to Pearson JT
Ministry of Education, Culture, Sports, Sciences and Technology of Japan to Shirai M
Corresponding Author James T Pearson, PhD, Monash Biomedical Imaging Facility, Monash University, 770 Blackburn Road, Clayton, Victoria 3168, Australia. james.pearson@monash.edu
Key Words Diabetes; Prediabetes; Insulin resistance; Myocardium; Sarcomere; Protein kinase C; Rho kinase
Core Tip Pathological changes in cardiac muscle under-lie diabetic cardiomyopathy (DCM) independent of hypertension and atherosclerosis. In advanced diabetes, fibrosis, hypertrophy and apoptosis, reduce myocardial compliance, which leads to increased diastolic filling pressures and overt left ventricular diastolic dysfunction. However, detrimental changes in sarcomeric and other cytoskeletal proteins in the cardiomyocytes of animal models of diabetes precede remodeling of the cardiac extracellular matrix, which has until now been considered the main contributor to diabetic diastolic dysfunction. An important target for preventing early DCM are the protein kinase C/rho-kinase pathways that drive oxidative stress and reduce myosin head cycling and prolong Ca2+ transients.
Publish Date 2015-07-10 18:24
Citation Waddingham MT, Edgley AJ, Tsuchimochi H, Kelly DJ, Shirai M, Pearson JT. Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy. World J Diabetes 2015; 6(7): 943-960
URL http://www.wjgnet.com/1948-9358/full/v6/i7/943.htm
DOI http://dx.doi.org/10.4239/wjd.v6.i7.943
Full Article (PDF) WJD-6-943.pdf
Full Article (Word) WJD-6-943.doc
Manuscript File 13560-Review.doc
Answering Reviewers 13560-Answering reviewers.pdf
Copyright License Agreement 13560-Copyright assignment.pdf
Peer-review Report 13560-Peer-review(s).pdf
Scientific Misconduct Check 13560-Scientific misconduct check.pdf
Scientific Editor Work List 13560-Scientific editor work list.pdf