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2/13/2015 9:30:00 AM | Browse: 1215 | Download: 1340
Publication Name World Journal of Hepatology
Manuscript ID 13575
Country/Territory Germany
Received
2014-08-27 17:42
Peer-Review Started
2014-08-29 17:18
To Make the First Decision
2014-10-14 17:52
Return for Revision
2014-10-17 10:27
Revised
2014-10-23 00:16
Second Decision
2014-11-12 14:03
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-11-19 11:29
Articles in Press
2014-11-19 11:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-28 09:36
Publish the Manuscript Online
2015-02-13 09:30
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Infectious Diseases
Manuscript Type Topic Highlights
Article Title Gene therapeutic approaches to inhibit hepatitis B virus replication
Manuscript Source Invited Manuscript
All Author List Maren Gebbing, Thorsten Bergmann, Eric Schulz and Anja Ehrhardt
Funding Agency and Grant Number
Funding Agency Grant Number
Else-Kröner-Fresenius-Foundation (EKFS)
UWH Forschungsförderung
Corresponding Author Anja Ehrhardt, PhD, Institute of Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, University Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58453 Witten, Germany. anja.ehrhardt@uni-wh.de
Key Words Gene therapy; Hepatitis B virus; Antisense nucleic acid; RNA interference; Designer nuclease; Ribozyme; DNAzyme; Dominant negative mutant; External guide sequence; DNA vaccination
Core Tip With various successful clinical trials ongoing, gene therapeutic approaches gained increasing attention in the community over the recent years. Here we introduce gene therapy as a versatile platform for treatment of hepatitis B (HBV) virus infection. Newest delivery methods based on non-viral and viral techniques combined with most advanced technologies for inhibition of HBV replication based on DNA, RNA and designer nucleases are discussed. An overview of various gene therapeutic systems which were explored in vitro and in vivo is provided. Advantages but also limitations of the different strategies to inhibit HBV replication are mentioned.
Publish Date 2015-02-13 09:30
Citation Gebbing M, Bergmann T, Schulz E, Ehrhardt A. Gene therapeutic approaches to inhibit hepatitis B virus replication. World J Hepatol 2015; 7(2): 150-164
URL http://www.wjgnet.com/1948-5182/full/v7/i2/150.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i2.150
Full Article (PDF) WJH-7-150.pdf
Full Article (Word) WJH-7-150.doc
Manuscript File 13575-Review.docx
Answering Reviewers 13575-Answering reviewers.pdf
Copyright License Agreement 13575-Copyright assignment.pdf
Peer-review Report 13575-Peer review(s).pdf
Scientific Misconduct Check 13575-CrossCheck.jpg
Scientific Editor Work List 13575-Scientific editor work list.pdf