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Articles Published Processes
2/13/2015 9:30:00 AM | Browse: 1358 | Download: 1612
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Received |
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2014-08-27 17:42 |
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Peer-Review Started |
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2014-08-29 17:18 |
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To Make the First Decision |
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2014-10-14 17:52 |
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Return for Revision |
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2014-10-17 10:27 |
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Revised |
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2014-10-23 00:16 |
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Second Decision |
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2014-11-12 14:03 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2014-11-19 11:29 |
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Articles in Press |
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2014-11-19 11:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-28 09:36 |
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Publish the Manuscript Online |
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2015-02-13 09:30 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Topic Highlights |
| Article Title |
Gene therapeutic approaches to inhibit hepatitis B virus replication
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maren Gebbing, Thorsten Bergmann, Eric Schulz and Anja Ehrhardt |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Else-Kröner-Fresenius-Foundation (EKFS) |
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| UWH Forschungsförderung |
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| Corresponding Author |
Anja Ehrhardt, PhD, Institute of Virology and Microbiology, Center for Biomedical Education and Research (ZBAF), Department of Human Medicine, Faculty of Health, University Witten/Herdecke, Alfred-Herrhausen-Straße 50, 58453 Witten, Germany. anja.ehrhardt@uni-wh.de |
| Key Words |
Gene therapy; Hepatitis B virus; Antisense nucleic acid; RNA interference; Designer nuclease; Ribozyme; DNAzyme; Dominant negative mutant; External guide sequence; DNA vaccination |
| Core Tip |
With various successful clinical trials ongoing, gene therapeutic approaches gained increasing attention in the community over the recent years. Here we introduce gene therapy as a versatile platform for treatment of hepatitis B (HBV) virus infection. Newest delivery methods based on non-viral and viral techniques combined with most advanced technologies for inhibition of HBV replication based on DNA, RNA and designer nucleases are discussed. An overview of various gene therapeutic systems which were explored in vitro and in vivo is provided. Advantages but also limitations of the different strategies to inhibit HBV replication are mentioned. |
| Publish Date |
2015-02-13 09:30 |
| Citation |
Gebbing M, Bergmann T, Schulz E, Ehrhardt A. Gene therapeutic approaches to inhibit hepatitis B virus replication. World J Hepatol 2015; 7(2): 150-164 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i2/150.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i2.150 |
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