Publication Name	World Journal of Diabetes
Manuscript ID	13582
Country	Iran

Received	2014-08-28 09:41
Peer-Review Started	2014-08-31 18:18
First Decision by Editorial Office Director
Return for Revision	2014-10-17 10:33
Revised	2014-10-25 17:32
Publication Fee Transferred
Second Decision by Editor	2014-12-29 18:25
Second Decision by Editor-in-Chief	2014-12-30 03:34
Final Decision by Editorial Office Director	2015-01-12 14:21
Articles in Press	2015-01-12 14:21
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-07 15:08
Publish the Manuscript Online	2015-04-20 09:13

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Developmental Biology
Manuscript Type	Review
Article Title	Some of the experimental and clinical aspects of the effects of the maternal diabetes on developing hippocampus
Manuscript Source	Invited Manuscript
All Author List	Javad Hami, Fatemeh Shojae, Saeed Vafaee-Nezhad, Nasim Lotfi, Hamed Kheradmand and Hossein Haghir
Funding Agency and Grant Number
Corresponding Author	Hossein Haghir, MD, PhD, Department of Anatomy and Cell Biology, School of Medicine, Mashdad University of Medical Sciences, Azadi Square, Mashhad 91857, Iran. haghirh@mums.ac.ir
Key Words	Maternal diabetes; Cognition complications; Teratogenic factor; Hippocampus
Core Tip	Diabetes mellitus is the most seriously metabolic condition in pregnancy that affects the hippo-campal development and function of the offspring. Multiple biological alterations, including hyperglycemia and hyperinsulinemia are occurring in maternal diabetes and impair the neurodevelopment of the fetus. Insulin-like growth factor-1 (IGF-1) and insulin are important regulators of development of central nervous system. It has clearly showed that maternal diabetes disturb the regulation of both insulin receptors and IGF-1 receptors in the hippocampus of rat newborn. This article is a brief review of the literatures that suggests a probable mechanism of how diabetes during pregnancy affects the hippocampus development in the offspring.
Publish Date	2015-04-20 09:13
Citation	Hami J, Shojae F, Vafaee-Nezhad S, Lotfi N, Kheradmand H, Haghir H. Some of the experimental and clinical aspects of the effects of the maternal diabetes on developing hippocampus. World J Diabetes 2015; 6(3): 412-422
URL	http://www.wjgnet.com/1948-9358/full/v6/i3/412.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i3.412

Full Article (PDF)	WJD-6-412.pdf
Full Article (Word)	WJD-6-412.doc
Manuscript File	13582-Review.docx
Answering Reviewers	13582-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13582-Conflict-of-interest statement.pdf
Copyright License Agreement	13582-Copyright assignment.pdf
Peer-review Report	13582-Peer review(s).pdf
Scientific Misconduct Check	13582-CrossCheck.jpg
Scientific Editor Work List	13582-Scientific editor work list.pdf