Publication Name	World Journal of Diabetes
Manuscript ID	13624
Country	Israel

Received	2014-08-28 17:35
Peer-Review Started	2014-08-28 19:31
To Make the First Decision	2014-09-16 10:53
Return for Revision	2014-09-19 17:49
Revised	2014-10-30 20:52
Second Decision	2014-12-26 08:38
Accepted by Journal Editor-in-Chief	2014-12-27 00:49
Accepted by Company Editor-in-Chief	2014-12-31 13:21
Articles in Press	2014-12-31 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-06 12:00
Publish the Manuscript Online	2015-03-19 18:00

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Impact of glucose level on morbidity and mortality in elderly with diabetes and pre-diabetes
Manuscript Source	Invited Manuscript
All Author List	Orit Twito, Meir Frankel and Dan Nabriski
Funding Agency and Grant Number
Corresponding Author	Dr. Orit Twito, Endocrinology, Diabetes and Metabolism Institute, Meir Medical Center, 59 Tschernihovsky, St., Kfar Saba 44281, Israel. orit.twito@clalit.org.il
Key Words	Diabetes mellitus; Elderly; Old age; Pre-diabetes; Glycemic control
Core Tip	The prevalence of diabetes mellitus (DM) and pre-diabetes in old age is very high. However, clinical guidelines do not provide complete information to the clinician managing patients with these conditions. Pre-diabetes status in the elderly increases the risk for DM, but probably does not increase the risk of cardiovascular morbidity and mortality. The role of therapeutic interventions in elderly patients with pre-diabetes is not yet proven. New-onset DM in older age is associated with better glycemic control and better prognosis compared to long standing DM in this population. Nevertheless, higher glucose levels in elderly with new-onset DM are associated with increased all-cause mortality. The benefits of tight glycemic control in elderly with long standing DM are doubtful and may cause more harm than good. To conclude, more research in this field is needed. Currently, the clinical approach for DM and pre-diabetes in the elderly should be tailored to meet individual needs.
Publish Date	2015-03-19 18:00
Citation	Twito O, Frankel M, Nabriski D. Impact of glucose level on morbidity and mortality in elderly with diabetes and pre-diabetes. World J Diabetes 2015; 6(2): 345-351
URL	http://www.wjgnet.com/1948-9358/full/v6/i2/345.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i2.345

Full Article (PDF)	WJD-6-345.pdf
Full Article (Word)	WJD-6-345.doc
Manuscript File	13624-Review.docx
Answering Reviewers	13624-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13624-Scientific editor work list.pdf
Copyright License Agreement	13624-Copyright assignment.pdf
Peer-review Report	13624-Peer review (s).pdf
Scientific Misconduct Check	13624-CrossCheck.jpg
Scientific Editor Work List	13624-Scientific editor work list.pdf