Publication Name	World Journal of Hepatology
Manuscript ID	13625
Country	South Korea

Received	2014-08-28 17:33
Peer-Review Started	2014-08-28 19:28
To Make the First Decision	2014-09-28 12:26
Return for Revision	2014-09-30 15:49
Revised	2014-10-12 18:26
Second Decision	2014-10-29 17:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-29 18:50
Articles in Press	2014-10-29 18:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-11-05 18:05
Typeset the Manuscript	2014-12-26 14:37
Publish the Manuscript Online	2015-01-10 16:31

ISSN	1948-5182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome
Manuscript Source	Invited Manuscript
All Author List	Young Min Park
Funding Agency and Grant Number
Corresponding Author	Young Min Park, MD, PhD, Hepatology Center, Department of Internal Medicine, Bundang Jesaeng General Hospital, 255-2, Seohyun-dong, Bundang-gu, Seongnam-si, Kyungki-do 463-774, South Korea. ymp1@outlook.com
Key Words	Hepatitis B virus; Point mutation; Hepatitis B virus X protein; Hepatocellular carcinoma; Cancer screening
Core Tip	Multiple mutations in the core promoter and proximal precore regions of the hepatitis B virus (HBV) genome are associated with hepatocellular carcinoma (HCC), but mutations predictive of outcome in chronic HBV carriers have not been distinguished. In the Korean HBV genotype C2, the number of mutations at eight key nucleotides located in these regions (G1613A, C1653T, T1753V, A1762T, G1764A, A1846T, G1896A, and G1899A) is positively correlated with HCC. In addition, some selected mutation combinations among individuals with ≥ 4 mutations are predominant in the HCC group.
Publish Date	2015-01-10 16:31
Citation	Park YM. Clinical utility of complex mutations in the core promoter and proximal precore regions of the hepatitis B virus genome. World J Hepatol 2015; 7(1): 113-120
URL	http://www.wjgnet.com/1948-5182/full/v7/i1/113.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i1.113

Full Article (PDF)	WJH-7-1.pdf
Full Article (Word)	WJH-7-1.doc
Manuscript File	13625-Review.docx
Answering Reviewers	13625-Answering reviewers.pdf
Copyright License Agreement	13625-Copyright assignment.pdf
Peer-review Report	13625-Peer review(s).pdf
Scientific Misconduct Check	13625-CrossCheck.jpg
Scientific Editor Work List	13625-Scientific editor work list.pdf