Publication Name	World Journal of Hepatology
Manuscript ID	13633
Country	China

Received	2014-08-28 17:56
Peer-Review Started	2014-08-28 19:16
To Make the First Decision	2014-10-14 18:08
Return for Revision	2014-10-20 17:16
Revised	2014-11-08 12:31
Second Decision	2015-04-01 14:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-07 16:26
Articles in Press	2015-04-07 16:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-18 13:47
Publish the Manuscript Online	2015-06-03 12:00

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Immunology
Manuscript Type	Review
Article Title	Chemokines and their receptors play important roles in the development of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin and Cui-Ping Zhong
Funding Agency and Grant Number	Funding Agency Grant Number National Science Foundation of China 31471147
Corresponding Author	Chun-Min Liang, MD, PhD, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, 138 Yixueyuan Road, Shanghai 200032, China. cmliang@fudan.edu.cn
Key Words	Chemokines; Hepatocellular carcinoma; Immune cells; Chemokine receptors; Inflammation; Angiogenesis; Tumor behaviors; Treatments
Core Tip	The chemokine system not only serves as the core components in orchestrating the normal immune response but also plays a key role in the microenvironment of hepatocellular carcinoma (HCC). Therefore, the thorough understanding of its role is indispensible for devising effective treatments. During the progress of HCC, the chemokine system boosts aberrant inflammation and angiogenesis through simultaneously affecting different kinds of immune cells and influencing the migration, invasion, growth and survival of tumor cells. Targeting the chemokine system has elicited powerful anti-tumor effects and this indicates an encouraging treatment option in HCC.
Publish Date	2015-06-03 12:00
Citation	Liang CM, Chen L, Hu H, Ma HY, Gao LL, Qin J, Zhong CP. Chemokines and their receptors play important roles in the development of hepatocellular carcinoma. World J Hepatol 2015; 7(10): 1390-1402
URL	http://www.wjgnet.com/1948-5182/full/v7/i10/1390.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i10.1390

Full Article (PDF)	WJH-7-1390.pdf
Full Article (Word)	WJH-7-1390.doc
Manuscript File	13633-Review.docx
Answering Reviewers	13633-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13633-Conflict-of-interest statement.pdf
Copyright License Agreement	13633-Copyright assignment.pdf
Peer-review Report	13633-Peer-review(s).pdf
Scientific Misconduct Check	13633-Scientific misconduct check.pdf
Scientific Editor Work List	13633-Scientific editor work list.pdf