Publication Name	World Journal of Hepatology
Manuscript ID	13638
Country	Japan

Received	2014-08-28 16:45
Peer-Review Started	2014-08-28 19:06
To Make the First Decision	2014-11-14 19:52
Return for Revision	2014-11-18 18:26
Revised	2014-11-27 00:11
Second Decision	2014-12-26 08:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-31 13:21
Articles in Press	2014-12-31 13:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-20 12:13
Publish the Manuscript Online	2015-03-31 15:58

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics
Manuscript Source	Invited Manuscript
All Author List	Yoshihiko Yano, Takeshi Azuma and Yoshitake Hayashi
Funding Agency and Grant Number	Funding Agency Grant Number Japan Initiative for Global Research Network on Infectious Disease (J-GRID) Program of the Ministry of Education, Culture, Sports, Science and Technology, Japan a SATREPS Grant from the Japan Science and Technology Agency and the Japan International Cooperation Agency Ministry of Health, Labour, and Welfare of Japan H25-general-008
Corresponding Author	Dr. Yoshihiko Yano, MD, PhD, Center for Infectious Diseases, Graduate School of Medicine, Kobe University, 7-5-1 Kusunoki-cho, Chuo-Ku, Kobe 650-0017, Japan. yanoyo@med.kobe-u.ac.jp
Key Words	Hepatitis B virus; Mutation; Quasispecies
Core Tip	Hepatitis B virus infection is major global issue. HBV spread worldwide with various mutations and variations. So far, thousands of studies reported that the variety of genome is closely related to the geographic distribution and clinical characteristics. Recent technological advances have made in easier to analyze mutations. Understanding of these variations is important for the development of diagnostic tools and the appropriate therapy for chronic hepatitis B.
Publish Date	2015-03-31 15:58
Citation	Yano Y, Azuma T, Hayashi Y. Variations and mutations in the hepatitis B virus genome and their associations with clinical characteristics. World J Hepatol 2015; 7(3): 583-592
URL	http://www.wjgnet.com/1948-5182/full/v7/i3/583.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i3.583

Full Article (PDF)	WJH-7-583.pdf
Full Article (Word)	WJH-7-583.doc
Manuscript File	13638-Review.docx
Answering Reviewers	13638-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13638-Conflict-of-interest statement.pdf
Copyright License Agreement	13638-Copyright assignment.pdf
Peer-review Report	13638-Peer review(s).pdf
Scientific Misconduct Check	13638-CrossCheck.jpg
Scientific Editor Work List	13638-Scientific editor work list.pdf