Publication Name	World Journal of Hepatology
Manuscript ID	13640
Country	South Africa

Received	2014-08-28 16:39
Peer-Review Started	2014-08-28 19:01
To Make the First Decision	2014-11-14 19:52
Return for Revision	2014-11-18 18:36
Revised	2014-12-18 21:02
Second Decision	2015-03-16 17:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-04-02 16:05
Articles in Press	2015-04-02 16:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-10 18:40
Publish the Manuscript Online	2015-05-20 16:43

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries
Manuscript Source	Invited Manuscript
All Author List	Hilmar K Lückhoff, Frederik C Kruger and Maritha J Kotze
Funding Agency and Grant Number
Corresponding Author	Hilmar K Lückhoff, MBChB, HonsBSc, Division of Anatomical Pathology, Department of Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, Bellville 7530, Cape Town, Western Cape, South Africa. hilmarklausl@gmail.com
Key Words	Liver biopsy; Genomics; Steatohepatitis; Non-invasive biomarkers; Histological severity; Non-alcoholic fatty liver disease
Core Tip	Non-alcoholic fatty liver disease (NAFLD) remains largely underdiagnosed and undertreated in general practice. In view of the limitations inherent to liver biopsy and peripheral surrogate biomarkers used in the diagnosis and assessment of histological severity in NAFLD, a number of composite prognostic models have entered the clinical domain as potentially viable alternatives. Lifestyle-based intervention remains the cornerstone of treatment in patients with NAFLD. The widespread clinical adoption of composite diagnostic and predictive models could however prove useful in informing clinical and therapeutic decision making with the goal of adding value to patient care across the NAFLD spectrum.
Publish Date	2015-05-20 16:43
Citation	Lückhoff HK, Kruger FC, Kotze MJ. Composite prognostic models across the non-alcoholic fatty liver disease spectrum: Clinical application in developing countries. World J Hepatol 2015; 7(9): 1192-1208
URL	http://www.wjgnet.com/1948-5182/full/v7/i9/1192.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i9.1192

Full Article (PDF)	WJH-7-1192.pdf
Full Article (Word)	WJH-7-1192.doc
Manuscript File	13640-Review.docx
Answering Reviewers	13640-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13640-Conflict-of-interest statement.pdf
Copyright License Agreement	13640-Copyright assignment.pdf
Peer-review Report	13640-Peer-review(s).pdf
Scientific Misconduct Check	13640-Scientific misconduct check.pdf
Scientific Editor Work List	13640-Scientific editor work list.pdf