Publication Name	World Journal of Gastroenterology
Manuscript ID	13660
Country	Japan

Received	2014-08-29 10:49
Peer-Review Started	2014-08-31 14:55
To Make the First Decision	2014-09-27 15:48
Return for Revision	2014-10-29 11:15
Revised	2014-12-09 23:07
Second Decision	2015-01-07 08:39
Accepted by Journal Editor-in-Chief	2015-01-10 00:37
Accepted by Executive Editor-in-Chief	2015-01-21 17:14
Articles in Press	2015-01-21 17:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-08 22:52
Typeset the Manuscript	2015-04-14 20:08
Publish the Manuscript Online	2015-04-20 15:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Impact of direct acting antiviral-based triple therapy on the serum alpha-fetoprotein level
Manuscript Source	Unsolicited Manuscript
All Author List	Koji Takayama, Norihiro Furusyo, Eiichi Ogawa, Hiroaki Ikezaki, Motohiro Shimizu, Masayuki Murata and Jun Hayashi
Funding Agency and Grant Number
Corresponding Author	Norihiro Furusyo, MD, PhD, Department of General Internal Medicine, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. furusyo@gim.med.kyushu-u.ac.jp
Key Words	Chronic hepatitis C; Hepatocellular carcinoma; Direct-acting antiviral agents; Telaprevir; Serum alpha-fetoprotein
Core Tip	The serum concentration of alpha-fetoprotein (AFP) is often elevated in patients with hepatocellular carcinoma (HCC), and a high AFP level has been reported to be a risk factor for the development of HCC by chronic hepatitis C patients. A recently introduced direct-acting antiviral agent, telaprevir (TVR), has been included in triple therapy regimens that include a protease inhibitor with conventional pegylated-interferon α (PEG-IFNα) and ribavirin (RBV), which has significantly improved the sustained virological response rate, up to 80% for patients with hepatitis C virus genotype 1. Regardless of virological response, TVR-based triple therapy more effectively reduces the serum alpha-fetoprotein level than does dual therapy with PEG-IFNα and RBV.
Publish Date	2015-04-20 15:10
Citation	Takayama K, Furusyo N, Ogawa E, Ikezaki H, Shimizu M, Murata M, Hayashi J. Direct-acting antiviral-based triple therapy on alpha-fetoprotein level in chronic hepatitis C patients. World J Gastroenterol 2015; 21(15): 4696-4706
URL	http://www.wjgnet.com/1007-9327/full/v21/i15/4696.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i15.4696

Full Article (PDF)	WJG-21-4696.pdf
Full Article (Word)	WJG-21-4696.doc
Manuscript File	13660-Review.docx
Answering Reviewers	13660-Answering reviewers.pdf
Biostatistics Review Certificate	13660-Biostatistics statement.pdf
Clinical Trial Registration Statement	13660-Clinical trial registration.pdf
Conflict-of-Interest Disclosure Form	13660-Conflict-of-interest statement.pdf
Copyright License Agreement	13660-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	13660-Clinical trial registration.pdf
Institutional Review Board Approval Form or Document	13660-Institutional review board statement.pdf
Peer-review Report	13660-Peer-review(s).pdf
Scientific Misconduct Check	13660-CrossCheck.jpg
Scientific Editor Work List	13660-Scientific editor work list.pdf