Publication Name	World Journal of Hepatology
Manuscript ID	13667
Country	Japan

Received	2014-08-29 10:36
Peer-Review Started	2014-08-31 16:50
To Make the First Decision	2014-11-14 18:55
Return for Revision	2014-11-19 13:28
Revised	2014-12-03 23:25
Second Decision	2014-12-29 18:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-02-02 20:10
Articles in Press	2015-02-02 20:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-23 16:34
Publish the Manuscript Online	2015-05-13 10:06

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Review
Article Title	Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful?
Manuscript Source	Invited Manuscript
All Author List	Akinobu Takaki and Kazuhide Yamamoto
Funding Agency and Grant Number
Corresponding Author	Akinobu Takaki, MD, Associate Professor, Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8558, Japan. akitaka@md.okayama-u.ac.jp
Key Words	Liver cancer; Liver cirrhosis; Hepatitis B; Hepatitis C; Non-alcoholic steatohepatitis; Reactive oxygen species
Core Tip	Oxidative stress is a key biological response that correlates with the progression of chronic liver disease. However, oxidative stress is an essential survival mechanism and thus to erase it is an unsuitable approach to disease control. As hepatocarcinogenesis is closely associated with increased oxidative stress via viral proteins or chronic inflammation and lipids, controlling oxidative stress should be effective against progressive liver disease. Agents that can control oxidative stress might represent a more effective approach than reactive oxygen species-scavenging agents.
Publish Date	2015-05-13 10:06
Citation	Takaki A, Yamamoto K. Control of oxidative stress in hepatocellular carcinoma: Helpful or harmful? World J Hepatol 2015; 7(7): 968-979
URL	http://www.wjgnet.com/1948-5182/full/v7/i7/968.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i7.968

Full Article (PDF)	WJH-7-968.pdf
Full Article (Word)	WJH-7-968.doc
Manuscript File	13667-Review.doc
Answering Reviewers	13667-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13667-Conflict-of-interest statement.pdf
Copyright License Agreement	13667-Copyright assignment.PDF
Peer-review Report	13667-Peer-review(s).pdf
Scientific Misconduct Check	13667-CrossCheck.jpg
Scientific Editor Work List	13667-Scientific editor work list.pdf