Publication Name	World Journal of Diabetes
Manuscript ID	13672
Country	Israel

Received	2014-08-29 10:29
Peer-Review Started	2014-08-30 20:22
To Make the First Decision	2014-11-14 18:55
Return for Revision	2014-11-19 13:42
Revised	2014-12-03 03:30
Second Decision	2014-12-11 08:48
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-17 16:49
Articles in Press	2014-12-17 16:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-08 16:28
Publish the Manuscript Online	2015-03-19 18:00

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Short and long term neuro-behavioral alterations in type 1 diabetes mellitus pediatric population
Manuscript Source	Invited Manuscript
All Author List	Edna Litmanovitch, Ronny Geva and Marianna Rachmiel
Funding Agency and Grant Number
Corresponding Author	Marianna Rachmiel, MD, Head of Pediatric and Adolescents, Diabetes Mellitus Service, Division of Pediatrics (Building 131), Assaf Haroffeh Medical Center, Zerifin section on 44 Road, Zerifin 70300, Israel. rmarianna@gmail.com
Key Words	Type 1 diabetes mellitus; Cognitive; Behavioral; Brain; Alterations; Children; Adolescences
Core Tip	Neurocognitive and behavioral functions vary with age and depend on interactions between multiple endogenous (brain structure, integrity) and exogenous (metabolic) factors. Understanding of brain development with age is an emerging field of research, and delineation of type 1 diabetes mellitus (T1DM) impact on those processes is even more challenging and unclear. We review the most recent information in a novel format, relevant for clinicians practicing pediatric medicine and diabetologists taking part in clinical oriented research, in order to clarify: what is known, what is its association to modifiable diabetes related aspects, what should clinicians pay attention to, and what is needed in future research. The available studies presented hereby already indicate the need for a change in the care of pediatric population with T1DM. Periodic psychological and neurological ongoing evaluation of children and youth with T1DM, including cognition specific questionnaires and direct testing, should be performed as part of clinical care, especially while taking into account patients’ daily and nocturnal glucose variability.
Publish Date	2015-03-19 18:00
Citation	Litmanovitch E, Geva R, Rachmiel M. Short and long term neuro-behavioral alterations in type 1 diabetes mellitus pediatric population. World J Diabetes 2015; 6(2): 259-270
URL	http://www.wjgnet.com/1948-9358/full/v6/i2/259.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i2.259

Full Article (PDF)	WJD-6-259.pdf
Full Article (Word)	WJD-6-259.doc
Manuscript File	13672-Review.doc
Answering Reviewers	13672-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13672-Conflict-of-interest statement.pdf
Copyright License Agreement	13672-Copyright assignment.pdf
Peer-review Report	13672-Peer review(s).pdf
Scientific Misconduct Check	13672-CrossCheck.jpg
Scientific Editor Work List	13672-Scientific editor work list.pdf