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Articles Published Processes
4/23/2015 12:08:00 PM | Browse: 1291 | Download: 1816
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Received |
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2014-08-29 08:29 |
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Peer-Review Started |
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2014-08-29 17:33 |
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To Make the First Decision |
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2014-10-14 18:03 |
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Return for Revision |
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2014-10-20 16:32 |
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Revised |
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2014-11-07 03:01 |
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Second Decision |
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2015-01-04 16:00 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-01-12 14:33 |
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Articles in Press |
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2015-01-12 14:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-03-30 11:33 |
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Publish the Manuscript Online |
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2015-04-23 12:08 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Matthew W Klinker and Cheng-Hong Wei |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| FDA Modernizing Science grant program |
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| FDA MCMi program |
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| Division of Cellular and Gene Therapies |
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| fellowship administered by the Oak Ridge Institute for Science and Education |
to Matthew W Klinker |
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| Corresponding Author |
Cheng-Hong Wei, PhD, Gene Transfer and Immunogenicity Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue, and Gene Therapies, Food and Drug Administration, Center for Biologics Evaluation and Research, 10903 New Hampshire Avenue, Building 52/72, Room 3104, Silver Spring, MD 20993-0002,
United States. chenghong.wei@fda.hhs.gov
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| Key Words |
Mesenchymal stromal cells; Mesenchymal stem cells; Autoimmunity; Animal models; Inflammation; Immunotherapy |
| Core Tip |
In this review, we summarize recent studies examining the effectiveness of mesenchymal stromal cells (MSCs) as immunotherapy in several widely-studied animal models, including type 1 diabetes, experimental autoimmune arthritis, experimental autoimmune ence?phalomyelitis, inflammatory bowel disease, graft-vs-host disease, and systemic lupus erythematosus. In addition, we discuss mechanisms identified by which MSCs mediate immune suppression in vivo and potential sources of functional variability of MSCs between studies. |
| Publish Date |
2015-04-23 12:08 |
| Citation |
Klinker MW, Wei CH. Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models. World J Stem Cells 2015; 7(3): 556-567 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i3/556.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i3.556 |
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