Publication Name	World Journal of Diabetes
Manuscript ID	13711
Country	United States

Received	2014-08-29 08:28
Peer-Review Started	2014-08-29 17:30
To Make the First Decision	2014-09-16 10:52
Return for Revision	2014-09-19 18:11
Revised	2014-09-23 06:24
Second Decision	2014-11-03 17:00
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-11-03 17:12
Articles in Press	2014-11-03 17:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-27 18:53
Publish the Manuscript Online	2014-12-13 19:01

ISSN	1948-9358 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart
Manuscript Source	Invited Manuscript
All Author List	Jia Zhao, Rushil Randive and James A Stewart
Funding Agency and Grant Number	Funding Agency Grant Number American Heart Association SDG5310006 (JAS) American Heart Association BGIA4150122 (JAS)
Corresponding Author	James A Stewart, PhD, Assistant Professor, Department of Biological Sciences, Mississippi State University, 220 Harned Hall, 295 Lee Boulevard, PO Box GY, Mississippi State, MS 39762, United States. jstewart@biology.msstate.edu
Key Words	Type 2 diabetes mellitus; Cardiac fibrosis; Fibroblasts; Advanced glycation end product; Rap1a; Extracellular matrix
Core Tip	Chronic hyperglycemia is a characteristic of diabetes and one of the major causal factors of diabetic complications. In type 2 diabetes mellitus, mechanical and biochemical stimuli activated profibrotic signaling cascades resulting in myocardial fibrosis, impaired cardiac performance, and ventricular stiffness. Glucose nonenzymatically reacts with extracellular matrix (ECM) proteins forming advanced glycation end products (AGEs). AGE-modified collagen increases matrix accumulation and stiffness by engaging the receptor for AGE (RAGE), the receptor for AGE. To date, our understanding of the AGE/RAGE cascade remains imprecise. This review discusses the AGE/RAGE signaling cascade and proposes an alternate role for Rap1a in diabetic cardiovascular ECM remodeling.
Publish Date	2014-12-13 19:01
Citation	Zhao J, Randive R, Stewart JA. Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart. World J Diabetes 2014; 5(6): 860-867
URL	http://www.wjgnet.com/1948-9358/full/v5/i6/860.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i6.860

Full Article (PDF)	WJD-5-860.pdf
Full Article (Word)	WJD-5-860.doc
Manuscript File	13711-Review.docx
Answering Reviewers	13711-Answering reviewers.pdf
Copyright License Agreement	13711-Copyright assignment.pdf
Peer-review Report	13711-Peer review(s).pdf
Scientific Misconduct Check	13711-CrossCheck.jpg
Scientific Editor Work List	13711-Scientific editor work list.pdf