Publication Name	World Journal of Stem Cells
Manuscript ID	13727
Country	United States

Received	2014-08-29 18:54
Peer-Review Started	2014-08-30 12:33
To Make the First Decision	2014-11-14 19:51
Return for Revision	2014-11-19 15:01
Revised	2014-11-25 03:43
Second Decision	2015-03-09 09:01
Accepted by Journal Editor-in-Chief	2015-03-09 16:45
Accepted by Executive Editor-in-Chief	2015-03-18 16:38
Articles in Press	2015-03-18 16:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-15 14:30
Publish the Manuscript Online	2015-05-31 19:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Scientific Journal
Manuscript Type	Minireviews
Article Title	Systems biology approach to developing S2RM-based “systems therapeutics” and naturally induced pluripotent stem cells
Manuscript Source	Invited Manuscript
All Author List	Greg Maguire and Peter Friedman
Funding Agency and Grant Number
Corresponding Author	Greg Maguire, PhD, SRM Living Foundry, BioRegenerative Sciences, Inc., 2658 Del Mar Heights Rd #416, San Diego, CA 92014, United States. gmaguire@srmfoundry.org
Key Words	Stem cell; Paracrine; Growth factors; Pluripotency; Wound healing; Cancer
Core Tip	A fundamentally new type of therapeutic, namely “systems therapeutic,” can be realized by reverse engineering the mechanisms of the stem cell released molecules (SRM) processes. Recent data demonstrates that the composition of the SRM is different for each type of stem cell, as well as for different states of each cell type. Although systems biology has been successfully used to analyze multiple pathways, the approach is often used to develop a small molecule interacting at only one pathway in the system. A new model is emerging in biology where systems biology is used to develop a new technology acting at multiple pathways called “systems therapeutics”.
Publish Date	2015-05-31 19:16
Citation	Maguire G, Friedman P. Systems biology approach to developing S2RM-based “systems therapeutics” and naturally induced pluripotent stem cells. World J Stem Cells 2015; 7(4): 745-756
URL	http://www.wjgnet.com/1948-0210/full/v7/i4/745.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i4.745

Full Article (PDF)	WJSC-7-745.pdf
Full Article (Word)	WJSC-7-745.doc
Manuscript File	13727-Review.docx
Answering Reviewers	13727-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13727-Conflict-of-interest statement.pdf
Copyright License Agreement	13727-Copyright assignment.pdf
Peer-review Report	13727-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13727-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13727-Scientific misconduct check.pdf
Scientific Editor Work List	13727-Scientific editor work list.pdf