Publication Name	World Journal of Hepatology
Manuscript ID	13750
Country	Egypt

Received	2014-08-30 11:59
Peer-Review Started	2014-08-30 17:34
To Make the First Decision	2014-09-28 12:23
Return for Revision	2014-10-08 09:56
Revised	2014-10-31 03:54
Second Decision	2015-05-04 19:21
Accepted by Journal Editor-in-Chief	2015-05-04 21:26
Accepted by Executive Editor-in-Chief	2015-05-27 15:02
Articles in Press	2015-05-27 15:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-05 08:37
Publish the Manuscript Online	2015-06-29 17:40

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Guide for diagnosis and treatment of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Magdy Hamed Attwa and Shahira Aly El-Etreby
Funding Agency and Grant Number
Corresponding Author	Magdy Hamed Attwa, MD, Division of Hepatology and Gastroenterology, Specialized Medical Hospital, Faculty of Medicine, Mansoura University, Mansoura 35516, Dakahlia Governorate, Egypt. magdyhamed52@hotmail.com
Key Words	Diagnosis of hepatocellular carcinoma; Surgical resection; Hepatocellular carcinoma; Liver transplantation; Radiofrequency ablation; Microwave ablation; Percutaneous ethanol or acetic acid ablation; Radio-embolisation; Systemic chemotherapy; Trans-arterial chemoembolisation
Core Tip	This review aims to spotlight on the different diagnostic modalities, and treatment options of hepatocellular carcinoma (HCC). Despite lack of adequate sensitivity of ultrasound (US) examination and alpha-fetoprotein, both are still considered the cornerstone for surveillance for HCC. So, a plethora of clinical studies searching for a more ideal tool are running. One of these tools is the microRNAs which can be considered as a promising diagnostic as well as prognostic tool for HCC. This review discusses the diagnostic utility of computed tomography and magnetic resonance imaging, as well as the enhanced US efficacy in diagnosis of HCC. Management of HCC depends on the tumour stage, liver function reserve, and patient performance status, and requires a multidisciplinary approach for optimal treatment. Liver transplantation and hepatic resection are the only curative options in early stage of disease. In addition, radiofrequency ablation is equivalent to surgical resection in well-selected patients. Radioembolization with use of resin or glass sphere appear promising. Novel molecular therapies are also discussed. For patients with advanced disease, sorafenib is the only approved therapy, but novel targeted agents and their combinations are emerging.
Publish Date	2015-06-29 17:40
Citation	Attwa MH, El-Etreby SA. Guide for diagnosis and treatment of hepatocellular carcinoma. World J Hepatol 2015; 7(12): 1632-1651
URL	http://www.wjgnet.com/1948-5182/full/v7/i12/1632.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i12.1632

Full Article (PDF)	WJH-7-1632.pdf
Full Article (Word)	WJH-7-1632.doc
Manuscript File	13750-Review.docx
Answering Reviewers	13750-Answering reviewers.pdf
Audio Core Tip	13750-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	13750-Conflict-of-interest statement.pdf
Copyright License Agreement	13750-Copyright asignment.pdf
Non-Native Speakers of English Editing Certificate	13750-Language certificate.pdf
Peer-review Report	13750-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13750-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13750-Scientific misconduct check.pdf
Scientific Editor Work List	13750-Scientific editor work list.pdf