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12/2/2015 12:01:00 PM | Browse: 526 | Download: 569
Publication Name World Journal of Hepatology
Manuscript ID 13764
Country of Manuscript Source Japan
Received
2014-09-01 09:04
Peer-Review Started
2014-09-03 16:10
To Make the First Decision
2014-09-28 12:31
Return for Revision
2014-10-06 16:48
Revised
2014-12-14 00:00
Second Decision
2014-12-25 18:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-12-31 13:18
Articles in Press
2014-12-31 13:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-03-20 12:16
Publish the Manuscript Online
2015-03-31 15:58
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Topic Highlights
Article Title Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia
Manuscript Source Invited Manuscript
All Author List Hiroshi Fukui
Funding Agency and Grant Number
Corresponding author Hiroshi Fukui, MD, PhD, Department of Gastroenterology, Endocrinology and Metabolism, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, Japan. hfukui@naramed-u.ac.jp
Keywords Gut-liver axis; Liver cirrhosis; Pathogenesis; Complications; Endotoxemia; Bacterial translocation; Leaky gut; Toll-like receptors; Selective intestinal decon­tamination; Probiotics
Core Tip A “leaky gut” may be the cutting edge for the passage of toxins, antigens or bacteria into the body, and may play a pathogenic role in advanced liver cirrhosis and its complications. More attention should be paid to the role of intestinal bacteria and bacterial products in the field of Hepatology. Here, I would like to overview the history of endotoxin assay in the blood, clinical significance of endotoxemia in liver cirrhosis and then shift to the topic of gut and liver in general. Understanding of the gut-liver axis, leaky gut and endotoxemia in cirrhosis may give us new ideas.
Publish Date 2015-03-31 15:58
Citation Fukui H. Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia. World J Hepatol 2015; 7(3): 425-442
Url http://www.wjgnet.com/1948-5182/full/v7/i3/425.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i3.425
Full Article (PDF) WJH-7-425.pdf
Full Article (Word) WJH-7-425.doc
Manuscript File 13764-Review.docx
Answering Reviewers 13764-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 13764-Conflict-of-interest statement.pdf
Copyright License Agreement 13764-Copyright assignment.pdf
Peer-review Report 13764-Peer review(s).pdf
Scientific Misconduct Check 13764-CrossCheck.jpg
Scientific Editor Work List 13764-Scientific editor work list.pdf