Publication Name	World Journal of Hepatology
Manuscript ID	13764
Country	Japan

Received	2014-09-01 09:04
Peer-Review Started	2014-09-03 16:10
To Make the First Decision	2014-09-28 12:31
Return for Revision	2014-10-06 16:48
Revised	2014-12-14 00:00
Second Decision	2014-12-25 18:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-31 13:18
Articles in Press	2014-12-31 13:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-20 12:16
Publish the Manuscript Online	2015-03-31 15:58

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia
Manuscript Source	Invited Manuscript
All Author List	Hiroshi Fukui
Funding Agency and Grant Number
Corresponding Author	Hiroshi Fukui, MD, PhD, Department of Gastroenterology, Endocrinology and Metabolism, Nara Medical University, 840 Shijo-cho Kashihara, Nara 634-8522, Japan. hfukui@naramed-u.ac.jp
Key Words	Gut-liver axis; Liver cirrhosis; Pathogenesis; Complications; Endotoxemia; Bacterial translocation; Leaky gut; Toll-like receptors; Selective intestinal decon­tamination; Probiotics
Core Tip	A “leaky gut” may be the cutting edge for the passage of toxins, antigens or bacteria into the body, and may play a pathogenic role in advanced liver cirrhosis and its complications. More attention should be paid to the role of intestinal bacteria and bacterial products in the field of Hepatology. Here, I would like to overview the history of endotoxin assay in the blood, clinical significance of endotoxemia in liver cirrhosis and then shift to the topic of gut and liver in general. Understanding of the gut-liver axis, leaky gut and endotoxemia in cirrhosis may give us new ideas.
Publish Date	2015-03-31 15:58
Citation	Fukui H. Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia. World J Hepatol 2015; 7(3): 425-442
URL	http://www.wjgnet.com/1948-5182/full/v7/i3/425.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i3.425

Full Article (PDF)	WJH-7-425.pdf
Full Article (Word)	WJH-7-425.doc
Manuscript File	13764-Review.docx
Answering Reviewers	13764-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13764-Conflict-of-interest statement.pdf
Copyright License Agreement	13764-Copyright assignment.pdf
Peer-review Report	13764-Peer review(s).pdf
Scientific Misconduct Check	13764-CrossCheck.jpg
Scientific Editor Work List	13764-Scientific editor work list.pdf