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Articles Published Processes
3/30/2015 5:46:00 PM | Browse: 1141 | Download: 1300
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Received |
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2014-09-01 09:00 |
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Peer-Review Started |
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2014-09-01 12:09 |
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To Make the First Decision |
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2014-10-14 16:43 |
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Return for Revision |
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2014-10-20 15:55 |
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Revised |
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2014-11-06 01:26 |
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Second Decision |
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2014-12-16 15:31 |
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Accepted by Journal Editor-in-Chief |
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2014-12-17 17:29 |
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Accepted by Executive Editor-in-Chief |
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2014-12-22 17:14 |
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Articles in Press |
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2014-12-22 17:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-01-06 09:00 |
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Typeset the Manuscript |
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2015-03-18 18:00 |
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Publish the Manuscript Online |
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2015-03-30 14:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing-Wen Zhang, Gui-Xin Zhang, Hai-Long Chen, Ge-Liang Liu, Lawrence Owusu, Yu-Xi Wang, Guan-Yu Wang and Cai-Ming Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81173452 |
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| Corresponding Author |
Hai-Long Chen, PhD, Professor of Medicine, Department of Surgery, The First Affiliated Hospital, Dalian Medical University, No. 222 Zhongshan Road, Dalian 116011, Liaoning Province, China. hailongchen2007@163.com |
| Key Words |
Intestinal barrier injury; Qingyi decoction; Secreted phospholipase A2; Severe acute pancreatitis; Verapamil |
| Core Tip |
Secreted phospholipase A2 (sPLA2) is a damage factor that stimulates excessive inflammatory responses, which can lead to the degradation and hydrolysis of biologic membranes, thus promoting epithelial injury. We demonstrate that sPLA2 is overexpressed at the mRNA and protein levels in a rat model of severe acute pancreatitis-induced intestinal barrier injury. However, a traditional Chinese medicine, Qingyi decoction, effectively antagonized this overexpression of sPLA2 to alleviate the severity of the disease. This observation was comparable to the inhibitory effect of verapamil on sPLA2 expression. |
| Publish Date |
2015-03-30 14:23 |
| Citation |
Zhang JW, Zhang GX, Chen HL, Liu GL, Owusu L, Wang YX, Wang GY, Xu CM. Therapeutic effect of Qingyi decoction in severe acute pancreatitis-induced intestinal barrier injury. World J Gastroenterol 2015; 21(12): 3537-3546 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i12/3537.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i12.3537 |
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