Publication Name	World Journal of Hepatology
Manuscript ID	13777
Country	China

Received	2014-09-01 08:14
Peer-Review Started	2014-09-01 19:15
To Make the First Decision	2014-10-14 17:51
Return for Revision	2014-10-17 11:29
Revised	2015-06-01 00:00
Second Decision	2015-07-07 17:13
Accepted by Journal Editor-in-Chief	2015-07-07 17:57
Accepted by Executive Editor-in-Chief	2015-07-17 13:56
Articles in Press	2015-07-17 13:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-20 12:24
Publish the Manuscript Online	2015-08-08 13:55

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy
Manuscript Source	Invited Manuscript
All Author List	Chuan Chen and Ge Wang
Funding Agency and Grant Number
Corresponding Author	Ge Wang, Professor, Cancer Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, No. 10 Changjiang Zhi Rd., Daping Yuzhong District, Chongqing 400042, China. wangge70@hotmail.com
Key Words	Hepatocellular carcinoma; Oncogene; Signal pathway; Cancer stem cell; Molecular targeted therapy
Core Tip	The molecular mechanism of hepatocar-cinogenesis is complex and is associated with the regulation function of a variety of signal transduction pathways and key molecules. Presently, there are many drugs that target the molecules that are involved in tumor development (molecule-targeted drugs), but the specificity of such drugs is lacking. This paper summarizes the targeted molecular drugs which may be useful for the clinical treatment of liver cancer, and lays the theoretical foundation for the further study of more specific and effective drugs that target the molecules involved in liver cancer.
Publish Date	2015-08-08 13:55
Citation	Chen C, Wang G. Mechanisms of hepatocellular carcinoma and challenges and opportunities for molecular targeted therapy. World J Hepatol 2015; 7(15): 1964-1970
URL	http://www.wjgnet.com/1948-5182/full/v7/i15/1964.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i15.1964

Full Article (PDF)	WJH-7-1964.pdf
Full Article (Word)	WJH-7-1964.doc
Manuscript File	13777-Review.docx
Answering Reviewers	13777-Answering reviewers.pdf
Audio Core Tip	13777-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	13777-Conflict-of-interest statement.pdf
Copyright License Agreement	13777-Copyright assignment.pdf
Peer-review Report	13777-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13777-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13777-Scientific misconduct check.pdf
Scientific Editor Work List	13777-Scientific editor work list.pdf