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Articles Published Processes
4/27/2015 4:29:00 PM | Browse: 1041 | Download: 1160
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Received |
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2014-09-03 08:16 |
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Peer-Review Started |
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2014-09-04 14:26 |
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To Make the First Decision |
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2014-10-14 16:51 |
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Return for Revision |
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2014-10-17 21:47 |
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Revised |
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2014-11-03 22:17 |
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Second Decision |
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2014-11-24 11:55 |
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Accepted by Journal Editor-in-Chief |
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2014-11-25 19:02 |
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Accepted by Executive Editor-in-Chief |
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2014-12-08 16:22 |
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Articles in Press |
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2014-12-08 17:15 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-12 18:23 |
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Publish the Manuscript Online |
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2015-04-27 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Murine study of portal hypertension associated endothelin-1 hypo-response
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Nicholas Theodorakis, Mary Maluccio and Nicholas Skill |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Indiana University department of surgery and Lilly INGEN research fund |
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| Corresponding Author |
Nicholas Skill, PhD, Assistant Research Professor, Department of Surgery, Division of Transplant Surgery, Indiana School of Medicine, Indiana University, Walthur Cancer Research Building, Rm C519. 980 W. Walnut Street, Indianapolis, IN 46202, United States. nskill@iupui.edu |
| Key Words |
Liver disease; Portal hypertension; Hyper-dynamic circulation; Endothelin-1; Nitric oxide synthase isoforms |
| Core Tip |
Portal hypertension (PHT) is a complication associated with vascular derangements in response to liver disease and fibrosis. Perturbations of nitric oxide (NO) and endothelin-1 are believed to be interrelated and play a key role in PHT vasculopathy. This study investigates the importance of NO biosynthesis in endothelin-1 vasoconstriction hypo-response seen in patients with PHT. PHT was induced in wild type, eNOS-/- and iNOS-/- mice by partial portal vein ligation (PVL) and endothelin-1 contractile response was determined. Endothelin-1 (ET-1) induced contraction was significantly reduced following PVL in all mouse groups. Aberrant ET-1 function associated with PHT is NO independent. |
| Publish Date |
2015-04-27 16:22 |
| Citation |
Theodorakis N, Maluccio M, Skill N. Murine study of portal hypertension associated endothelin-1 hypo-response. World J Gastroenterol 2015; 21(16): 4817-4828 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i16/4817.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i16.4817 |
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