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Articles Published Processes
4/7/2015 6:08:00 PM | Browse: 1134 | Download: 2066
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Received |
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2014-09-03 17:45 |
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Peer-Review Started |
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2014-09-04 16:19 |
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To Make the First Decision |
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2014-09-27 16:34 |
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Return for Revision |
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2014-10-10 08:35 |
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Revised |
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2014-11-07 23:36 |
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Second Decision |
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2014-12-08 14:44 |
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Accepted by Journal Editor-in-Chief |
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2014-12-10 09:52 |
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Accepted by Executive Editor-in-Chief |
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2014-12-16 10:16 |
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Articles in Press |
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2014-12-16 10:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-30 09:06 |
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Typeset the Manuscript |
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2015-03-24 15:58 |
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Publish the Manuscript Online |
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2015-04-07 17:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chih-Chi Kuo, Yu-Lueng Shih, Her-Young Su, Ming-De Yan, Chung-Bao Hsieh, Chin-Yu Liu, Wei-Ting Huang, Mu-Hsien Yu and Ya-Wen Lin |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science Council, Taiwan |
NSC 102-2320-B-016-016-MY3 |
| Liver Disease Prevention and Treatment Research Foundation, Taiwan |
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| Corresponding Author |
Ya-Wen Lin, PhD, Department and Graduate Institute of Microbiology and Immunology, Graduate Institute of Medical Sciences, National Defense Medical Center, No. 161, Section 6, Min-Chuan East Road, Taipei 114, Taiwan. ndmc.yawen@msa.hinet.net |
| Key Words |
IRAK3; GLOXD1; Hepatocellular carcinoma; DNA methylation biomarker; Quantitative methylation-specific polymerase chain reaction; Pyrosequencing |
| Core Tip |
The methylation biomarker is relatively stable in tissue samples and body fluids, suggesting that it is a good tool for the detection, diagnosis, prognosis, and even therapy of hepatocellular carcinoma (HCC). Our study not only demonstrated frequent methylation of interleukin-1 receptor-associated kinase 3 (IRAK3) and GLOXD1 in HCC but also found that IRAK3 methylation was positively associated with poor 3-year disease-free survival of patients. This indicates that IRAK3 methylation could be used as a potential biomarker for prediction of prognosis in HCC. |
| Publish Date |
2015-04-07 17:13 |
| Citation |
Kuo CC, Shih YL, Su HY, Yan MD, Hsieh CB, Liu CY, Huang WT, Yu MH, Lin YW. Methylation of IRAK3 is a novel prognostic marker in hepatocellular carcinoma. World J Gastroenterol 2015; 21(13): 3960-3969 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i13/3960.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i13.3960 |
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