| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virus -infected liver
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Motoyuki Kohjima, Tsuyoshi Yoshimoto, Munechika Enjoji, Nobuyoshi Fukushima, Kunitaka Fukuizumi, Tsukasa Nakamura, Miho Kurokawa, Nao Fujimori, Yusuke Sasaki, Yasushi Shimonaka, Yusuke Murata, Susumu Koyama, Ken Kawabe, Kazuhiro Haraguchi, Yorinobu Sumida, Naohiko Harada, Masaki Kato, Kazuhiro Kotoh and Makoto Nakamuta |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Intractable Disease provided by the Ministry of Health, Labor and Welfare of Japan |
|
| Clinical Research from the National Hospital Organization of Japan |
|
|
| Corresponding Author |
Munechika Enjoji, MD, PhD, Health Care Center, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. enjoji@adm.fukuoka-u.ac.jp |
| Key Words |
Chronic hepatitis C; Iron-metabolism; Hepcidin; Ferroportin; Interferon |
| Core Tip |
The first showing the relationship between expression of iron-metabolism-related genes and response to pegylated-interferon (peg-IFN) and ribavirin (RBV) therapy in patients with chronic hepatitis C. The expression of hepcidin and ferroportin in the liver before therapy was significantly lower in sustained virological response (SVR) patients than non-SVR patients. The expression of hepcidin was positively correlated with that of ferroportin. The variation in hepatic expression profile in iron-metabolism-related genes is important for the response to peg-IFN + RBV treatment. |
| Publish Date |
2015-03-19 16:57 |
| Citation |
Kohjima M, Yoshimoto T, Enjoji M, Fukushima N, Fukuizumi K, Nakamura T, Kurokawa M, Fujimori N, Sasaki Y, Shimonaka Y, Murata Y, Koyama S, Kawabe K, Haraguchi K, Sumida Y, Harada N, Kato M, Kotoh K, Nakamuta M. Hepcidin/ferroportin expression levels involve efficacy of pegylated-interferon plus ribavirin in hepatitis C virus-infected liver. World J Gastroenterol 2015; 21(11): 3291-3299 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i11/3291.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i11.3291 |
