Publication Name	World Journal of Gastroenterology
Manuscript ID	13857
Country	Argentina

Received	2014-09-04 08:15
Peer-Review Started	2014-09-04 17:11
To Make the First Decision	2014-10-14 16:50
Return for Revision	2014-10-17 21:54
Revised	2014-10-18 01:56
Second Decision	2014-12-08 14:44
Accepted by Journal Editor-in-Chief	2014-12-10 09:51
Accepted by Company Editor-in-Chief	2014-12-16 10:17
Articles in Press	2014-12-16 10:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-13 10:15
Publish the Manuscript Online	2015-01-20 20:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Liver enzymes, metabolomics and GWAS: From systems biology to the personalized medicine
Manuscript Source	Invited Manuscript
All Author List	Silvia Sookoian and Carlos J Pirola
Funding Agency and Grant Number	Funding Agency Grant Number PICT 2010-0441(in part) PICT 2012-0159(in part) UBACYT CM04
Corresponding Author	Silvia Sookoian, MD, PhD, Department of Clinical and Molecular Hepatology, Institute of Medical Research A Lanari-IDIM, University of Buenos Aires – National Scientific and Technical Research Council (CONICET), Ciudad Autónoma de Buenos Aires, Combatiente de Malvinas 3150, Buenos Aires 1427, Argentina. sookoian.silvia@lanari.fmed.uba.ar
Key Words	Transaminases; Aminotransferases; Alanine-aminotransferase; Aspartate-aminotransferase; Glutamate-oxalacetate transaminase; Glutamate-pyruvate transaminase; Glutamic acid; Metabolism; Nonalcoholic fatty liver; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Gene variants; Single nucleotide polymorphisms; PNPLA3; Genetics; Metabolomics; Metabolic syndrome; Systems biology
Core Tip	Genomic, transcriptomic, proteomic, and metabolomic information has changed the classical conception of the meaning that serum concentrations of alanine-aminotransferase (ALT) and ALT are merely indicators of hepatocyte membrane disruption. It has given way to a more complex and interconnected view of the importance of liver transaminases in the regulation of systemic metabolic function.
Publish Date	2015-01-20 20:12
Citation	Sookoian S, Pirola CJ. Liver enzymes, metabolomics and genome-wide association studies: From systems biology to the personalized medicine. World J Gastroenterol 2015; 21(3): 711-725
URL	http://www.wjgnet.com/1007-9327/full/v21/i3/711.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i3.711

Full Article (PDF)	WJG-21-711.pdf
Full Article (Word)	WJG-21-711.doc
Manuscript File	13857-Review.doc
Answering Reviewers	13857-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13857-Conflict-of-interest statement.pdf
Copyright License Agreement	13857-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	13857-Language certificate.pdf
Peer-review Report	13857-Peer review(s).pdf
Scientific Misconduct Check	13857-CrossCheck.jpg
Scientific Editor Work List	13857-Scientific editor work list.pdf