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2/11/2015 4:38:00 PM | Browse: 1071 | Download: 1723
Publication Name World Journal of Gastroenterology
Manuscript ID 13860
Country/Territory United States
Received
2014-09-04 08:09
Peer-Review Started
2014-09-04 17:12
To Make the First Decision
2014-10-29 14:59
Return for Revision
2014-10-31 17:10
Revised
2014-11-06 06:59
Second Decision
2014-12-08 14:45
Accepted by Journal Editor-in-Chief
2014-12-10 09:43
Accepted by Company Editor-in-Chief
2014-12-16 10:17
Articles in Press
2014-12-16 10:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-26 14:44
Publish the Manuscript Online
2015-02-11 16:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing
Manuscript Source Invited Manuscript
All Author List Rajagopal N Aravalli, Neil C Talbot and Clifford J Steer
Funding Agency and Grant Number
Funding Agency Grant Number
Departmental funds to Dr. Aravalli RN
Corresponding Author Rajagopal N Aravalli, PhD, Department of Radiology, University of Minnesota Medical School, MMC 292 Mayo, 420 Delaware Street SE, Minneapolis, MN 55455, United States. arava001@umn.edu
Key Words Hepatocellular carcinoma; MYC; Stem cells; Gene expression; RNA sequencing
Core Tip It is well-established that cancer stem cells not only drive tumor growth in the liver, in general, but also that the proto-oncogene c-MYC plays a critical role in that process. However, little is known about genes induced and regulated by MYC to generate tumors, and, in particular, those involved in liver stem cells. In this study, we examined the role of MYC protein in hepatocarcinogenesis using an immortal porcine liver stem cell line, PICM-19. Interestingly, MYC-overexpression silenced the expression of six genes in PICM-19 cells (CDO1, C22orf39, DKK2, ENPEP, GPX6, SRPX2), suggesting that they may be critical in inducing tumorigenesis.
Publish Date 2015-02-11 16:38
Citation Aravalli RN, Talbot NC, Steer CJ. Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing. World J Gastroenterol 2015; 21(7): 2011-2029
URL http://www.wjgnet.com/1007-9327/full/v21/i7/2011.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i7.2011
Full Article (PDF) WJG-21-2011.pdf
Full Article (Word) WJG-21-2011.doc
Manuscript File 13860-Review.docx
Answering Reviewers 13860-Answering reviewers.pdf
Biostatistics Review Certificate 13860-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 13860-Conflict-of-interest statement.pdf
Copyright License Agreement 13860-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 13860-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 13860-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 13860-Language certificate.pdf
Peer-review Report 13860-Peer review(s).pdf
Scientific Misconduct Check 13860-CrossCheck.jpg
Scientific Editor Work List 13860-Scientific editor work list.pdf