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Articles Published Processes
2/11/2015 4:38:00 PM | Browse: 1199 | Download: 2094
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Received |
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2014-09-04 08:09 |
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Peer-Review Started |
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2014-09-04 17:12 |
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To Make the First Decision |
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2014-10-29 14:59 |
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Return for Revision |
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2014-10-31 17:10 |
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Revised |
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2014-11-06 06:59 |
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Second Decision |
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2014-12-08 14:45 |
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Accepted by Journal Editor-in-Chief |
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2014-12-10 09:43 |
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Accepted by Executive Editor-in-Chief |
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2014-12-16 10:17 |
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Articles in Press |
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2014-12-16 10:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-01-26 14:44 |
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Publish the Manuscript Online |
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2015-02-11 16:38 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rajagopal N Aravalli, Neil C Talbot and Clifford J Steer |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Departmental funds |
to Dr. Aravalli RN |
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| Corresponding Author |
Rajagopal N Aravalli, PhD, Department of Radiology, University of Minnesota Medical School, MMC 292 Mayo, 420 Delaware Street SE, Minneapolis, MN 55455, United States. arava001@umn.edu
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| Key Words |
Hepatocellular carcinoma; MYC; Stem cells; Gene expression; RNA sequencing |
| Core Tip |
It is well-established that cancer stem cells not only drive tumor growth in the liver, in general, but also that the proto-oncogene c-MYC plays a critical role in that process. However, little is known about genes induced and regulated by MYC to generate tumors, and, in particular, those involved in liver stem cells. In this study, we examined the role of MYC protein in hepatocarcinogenesis using an immortal porcine liver stem cell line, PICM-19. Interestingly, MYC-overexpression silenced the expression of six genes in PICM-19 cells (CDO1, C22orf39, DKK2, ENPEP, GPX6, SRPX2), suggesting that they may be critical in inducing tumorigenesis. |
| Publish Date |
2015-02-11 16:38 |
| Citation |
Aravalli RN, Talbot NC, Steer CJ. Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing. World J Gastroenterol 2015; 21(7): 2011-2029 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i7/2011.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i7.2011 |
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