Publication Name	World Journal of Stem Cells
Manuscript ID	13864
Country	Czech Republic

Received	2014-09-04 20:09
Peer-Review Started	2014-09-05 09:35
To Make the First Decision	2014-12-17 11:28
Return for Revision	2014-12-23 13:44
Revised	2015-05-22 00:55
Second Decision	2015-08-07 17:46
Accepted by Journal Editor-in-Chief	2015-08-07 20:18
Accepted by Executive Editor-in-Chief	2015-08-14 16:16
Articles in Press	2015-08-14 16:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-10 19:09
Publish the Manuscript Online	2015-09-25 17:30

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases
Manuscript Source	Invited Manuscript
All Author List	Antonin Bukovsky
Funding Agency and Grant Number
Corresponding Author	Antonin Bukovsky, MD, PhD, DSc, Professor, The Institute of Biotechnology, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 14220, Czech Republic. a_buko@comcast.net
Key Words	Cellular differentiation; Endogenous stem cells; Neurological disorders; Regenerative medicine; Sex steroid combinations; Stem cell niche; Treatment of aging diseases
Core Tip	Sex steroid combinations have been found to transdifferentiate in vitro the vascular smooth muscle cells into neurons. Therefore, utilization of sex steroid combinations may enable regeneration of neural tissues affected by acute/traumatic disorders. In aging individuals, however, an altered immune system components in the stem cell niche may be unable to preserve regenerating cells in the functional stage due to the immune system regression with age advancement. This could be improved by transfer of blood mononuclear cells from young healthy individuals. Beside that, the local and systemic utilization of honey bee propolis alone has been found to ameliorate some age-induced disorders.
Publish Date	2015-09-25 17:30
Citation	Bukovsky A. From cellular to chemical approach for acute neural and alternative options for age-induced functional diseases. World J Stem Cells 2015; 7(8): 1109-1117
URL	http://www.wjgnet.com/1948-0210/full/v7/i8/1109.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i8.1109

Full Article (PDF)	WJSC-7-1109.pdf
Full Article (Word)	WJSC-7-1109.doc
Manuscript File	13864-Review.docx
Answering Reviewers	13864-Answering reviewers.pdf
Audio Core Tip	13864-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	13864-Conflict-of-interest statement.pdf
Copyright License Agreement	13864-Copyright assignment.pdf
Peer-review Report	13864-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13864-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13864-Scientific misconduct check.pdf
Scientific Editor Work List	13864-Scientific editor work list.pdf