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Articles Published Processes
3/16/2015 6:04:00 PM | Browse: 1705 | Download: 2275
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Received |
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2014-09-05 08:24 |
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Peer-Review Started |
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2014-09-05 17:52 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-09-30 15:56 |
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Revised |
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2014-10-10 22:13 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-11-24 11:56 |
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Second Decision by Editor-in-Chief |
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2014-11-25 19:26 |
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Final Decision by Editorial Office Director |
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2014-12-08 16:37 |
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Articles in Press |
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2014-12-08 17:15 |
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Edit the Manuscript by Language Editor |
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2014-12-16 20:53 |
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Typeset the Manuscript |
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2015-03-04 12:03 |
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Publish the Manuscript Online |
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2015-03-16 18:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Increased VGLUT3 involved in visceral hyperalgesia in a rat model of irritable bowel syndrome
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chang-Qing Yang, Li-Ping Duan, Pei-Tang Qiao, Li Zhao and Li-Li Guo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
30940033 |
| Doctoral Program of Higher Education of China |
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| Corresponding Author |
Chang-Qing Yang, PhD, Department of Gastroenterology, Peace Hospital, Changzhi Medical College, 110 South Yan-an Rd., Changzhi 046000, Shanxi Province, China. yangchangqing111@sohu.com |
| Key Words |
Vesicular glutamate transporter-3; Irritable bowel syndrome; Mast cell; Infection; Stress; Neuron |
| Core Tip |
It has been shown that visceral hyperalgesia in response to various stimuli from the gut of irritable bowel syndrome (IBS) patients is an important factor in abdominal pain. Our research indicated that the vesicular glutamate transporter 3 (VGLUT3), which concentrates the excitatory neurotransmitter glutamate into synaptic vesicles in peripheral and central neurons, is involved in the pathogenesis of visceral hyperalgesia. An infection-induced increase in VGLUT3 may be one of the main reasons for visceral hyperalgesia in IBS patients. |
| Publish Date |
2015-03-16 18:04 |
| Citation |
Yang CQ, Duan LP, Qiao PT, Zhao L, Guo LL. Increased VGLUT3 involved in visceral hyperalgesia in a rat model of irritable bowel syndrome. World J Gastroenterol 2015; 21(10): 2959-2966
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| URL |
http://www.wjgnet.com/1007-9327/full/v21/i10/2959.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i10.2959 |
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