Publication Name	World Journal of Gastroenterology
Manuscript ID	13891
Country	China

Received	2014-09-06 11:54
Peer-Review Started	2014-09-07 18:28
To Make the First Decision	2014-10-14 16:50
Return for Revision	2014-10-20 08:56
Revised	2014-11-01 10:17
Second Decision	2014-11-27 21:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-12-01 13:54
Articles in Press	2014-12-01 14:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-12-08 17:39
Typeset the Manuscript	2015-01-04 20:47
Publish the Manuscript Online	2015-01-20 20:12

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of E3 ubiquitin ligases in gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Ya-Chao Hou and Jing-Yu Deng
Funding Agency and Grant Number
Corresponding Author	Jing-Yu Deng, MD, PhD, Department of Gastroenterology, Cancer Hospital of Tianjin Medical University, City Key Laboratory of Tianjin Cancer Center, and National Clinical Research Center of Cancer, Huanhuxi Road, Hexi District, Tianjin 300060, China. dengery@126.com
Key Words	E3 ubiquitin ligases; Gastric cancer; Oncogene; Tumor suppressor gene; Target therapy
Core Tip	E3 biquitin ligases are a large family of proteins that catalyze the ubiquitination of many protein substrates for targeted degradation by the 26S proteasome. They are play an essential role in a variety of biological processes including cell cycle regulation, proliferation and apoptosis. They are often found overexpressed and their deregulation has been shown to contribute to gastric cancer（GC）development. The mechanisms of E3 ubiquitin ligases regulation the biological functions and their exact roles in carcinogenesis can help to develop specific E3 ubiquitin ligase inhibitors to improve the treatment strategies for GC patients.
Publish Date	2015-01-20 20:12
Citation	Hou YC, Deng JY. Role of E3 ubiquitin ligases in gastric cancer. World J Gastroenterol 2015; 21(3): 786-793
URL	http://www.wjgnet.com/1007-9327/full/v21/i3/786.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i3.786

Full Article (PDF)	WJG-21-786.pdf
Full Article (Word)	WJG-21-786.doc
Manuscript File	13891-Review.doc
Answering Reviewers	13891-Answering reviewers.pdf
Copyright License Agreement	13891-Copyright assignment.pdf
Peer-review Report	13891-Peer review(s).pdf
Scientific Misconduct Check	13891-CrossCheck.jpg
Scientific Editor Work List	13891-Scientific editor work list.pdf