Publication Name	World Journal of Diabetes
Manuscript ID	13932
Country	Iran

Received	2014-09-09 08:09
Peer-Review Started	2014-09-09 15:04
First Decision by Editorial Office Director
Return for Revision	2014-10-20 08:11
Revised	2014-11-03 21:06
Publication Fee Transferred
Second Decision by Editor	2014-12-10 11:31
Second Decision by Editor-in-Chief	2014-12-11 18:48
Final Decision by Editorial Office Director	2014-12-17 16:21
Articles in Press	2014-12-17 16:21
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-01-15 16:58
Publish the Manuscript Online	2015-01-31 14:38

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus
Manuscript Source	Invited Manuscript
All Author List	Ahmad Ghorbani and Reza Shafiee-Nick
Funding Agency and Grant Number	Funding Agency Grant Number Mashhad University of Medical Sciences
Corresponding Author	Reza Shafiee-Nick, Pharm D, PhD, Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Pardis Campus, Azadi Square, 91375-3316 Mashhad, Iran. shafieer@mums.ac.ir
Key Words	C-peptide; Diabetes; Insulin; Nephropathy; Neuropathy
Core Tip	In type-1 diabetes, in addition to decrease of endogenous insulin, the plasma level of connecting peptide (C-peptide) is also reduced due to beta cell destruction. Therefore, it may be possible that C-peptide deficiency be involved in the development of diabetic complications such as retinopathy, nephropathy, neuropathy and cardiovascular diseases. In this paper, beneficial effects of C-peptide replacement on pathological features associated with type-1 diabetes are described. Also, experimental and clinical findings that support the hypoglycemic, antilipolytic and vasodilator effects of C-peptide are discussed.
Publish Date	2015-01-31 14:38
Citation	Ghorbani A, Shafiee-Nick R. Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus. World J Diabetes 2015; 6(1): 145-150
URL	http://www.wjgnet.com/1948-9358/full/v6/i1/145.htm
DOI	http://dx.doi.org/10.4239/wjd.v6.i1.145

Full Article (PDF)	WJD-6-145.pdf
Full Article (Word)	WJD-6-145.doc
Manuscript File	13932-Review.doc
Answering Reviewers	13932-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13932-Conflict-of-interest.pdf
Copyright License Agreement	13932-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	13932-Language certificate.pdf
Peer-review Report	13932-Peer review(s).pdf
Scientific Misconduct Check	13932-CorssCheck.jpg
Scientific Editor Work List	13932-Scientific editor work list.pdf