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1/31/2015 2:38:00 PM | Browse: 484 | Download: 743
Publication Name World Journal of Diabetes
Manuscript ID 13932
Country of Manuscript Source Iran
Received
2014-09-09 08:09
Peer-Review Started
2014-09-09 15:04
To Make the First Decision
2014-10-14 17:32
Return for Revision
2014-10-20 08:11
Revised
2014-11-03 21:06
Second Decision
2014-12-10 11:31
Accepted by Journal Editor-in-Chief
2014-12-11 18:48
Accepted by Company Editor-in-Chief
2014-12-17 16:21
Articles in Press
2014-12-17 16:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-01-15 16:58
Publish the Manuscript Online
2015-01-31 14:38
ISSN 1948-9358 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Endocrinology and Metabolism
Manuscript Type Review
Article Title Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus
Manuscript Source Invited Manuscript
All Author List Ahmad Ghorbani and Reza Shafiee-Nick
Funding Agency and Grant Number
Funding Agency Grant Number
Mashhad University of Medical Sciences
Corresponding author Reza Shafiee-Nick, Pharm D, PhD, Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Pardis Campus, Azadi Square, 91375-3316 Mashhad, Iran. shafieer@mums.ac.ir
Keywords C-peptide; Diabetes; Insulin; Nephropathy; Neuropathy
Core Tip In type-1 diabetes, in addition to decrease of endogenous insulin, the plasma level of connecting peptide (C-peptide) is also reduced due to beta cell destruction. Therefore, it may be possible that C-peptide deficiency be involved in the development of diabetic complications such as retinopathy, nephropathy, neuropathy and cardiovascular diseases. In this paper, beneficial effects of C-peptide replacement on pathological features associated with type-1 diabetes are described. Also, experimental and clinical findings that support the hypoglycemic, antilipolytic and vasodilator effects of C-peptide are discussed.
Publish Date 2015-01-31 14:38
Citation Ghorbani A, Shafiee-Nick R. Pathological consequences of C-peptide deficiency in insulin-dependent diabetes mellitus. World J Diabetes 2015; 6(1): 145-150
Url http://www.wjgnet.com/1948-9358/full/v6/i1/145.htm
DOI http://dx.doi.org/10.4239/wjd.v6.i1.145
Full Article (PDF) WJD-6-145.pdf
Full Article (Word) WJD-6-145.doc
Manuscript File 13932-Review.doc
Answering Reviewers 13932-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form 13932-Conflict-of-interest.pdf
Copyright License Agreement 13932-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 13932-Language certificate.pdf
Peer-review Report 13932-Peer review(s).pdf
Scientific Misconduct Check 13932-CorssCheck.jpg
Scientific Editor Work List 13932-Scientific editor work list.pdf