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Articles Published Processes
6/29/2015 4:40:00 PM | Browse: 1210 | Download: 1389
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Received |
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2014-09-09 18:31 |
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Peer-Review Started |
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2014-09-10 13:37 |
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To Make the First Decision |
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2014-10-14 16:58 |
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Return for Revision |
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2014-10-17 08:04 |
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Revised |
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Second Decision |
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2014-12-26 13:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-01-08 17:20 |
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Articles in Press |
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2015-01-08 17:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-05-21 18:35 |
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Typeset the Manuscript |
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2015-05-29 17:56 |
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Publish the Manuscript Online |
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2015-06-29 16:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Immunohistochemical CD3 staining detects additional patients with celiac disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Amani Mubarak, Victorien M Wolters, Roderick HJ Houwen and Fiebo JW ten Kate |
| Funding Agency and Grant Number |
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| Corresponding Author |
Amani Mubarak, MD, PhD, Department of Pediatric Gastroenterology, University Medical Center Utrecht, Wilhelmina Children’s Hospital, PO BOX 85090, 3508 AB Utrecht, The Netherlands. dr.amani.mubarak@gmail.com |
| Key Words |
Celiac disease; Diagnosis; Intra-epithelial lymphocytosis; Histology; Marsh classification; CD3 staining |
| Core Tip |
Intra-epithelial lymphocytosis is considered to be the most important histological finding in celiac disease and therefore provides the key to a correct diagnosis. However, when evaluating the number of intra-epithelial lymphocytes on hematoxylin and eosin stained sections, the lack of contrast between the cells might cause diagnostic difficulties. In this study, we showed that performing CD3 staining improves the histological diagnosis of celiac disease. In fact, this study demonstrated that CD3 staining should be performed when there is a discrepancy between serology and the histological evaluation on routine sections. |
| Publish Date |
2015-06-29 16:33 |
| Citation |
Mubarak A, Wolters VM, Houwen RHJ, ten Kate FJW. Immunohistochemical CD3 staining detects additional patients with celiac disease. World J Gastroenterol 2015; 21(24): 7553-7557 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i24/7553.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i24.7553 |
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