BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
4/30/2015 2:11:00 PM | Browse: 1071 | Download: 593
 |
Received |
|
2014-09-10 19:22 |
|
Peer-Review Started |
|
2014-09-11 19:57 |
|
To Make the First Decision |
|
2014-10-14 16:58 |
|
Return for Revision |
|
2014-10-17 08:06 |
|
Revised |
|
2014-11-11 19:47 |
|
Second Decision |
|
2014-12-26 13:42 |
 |
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2015-01-08 17:21 |
|
Articles in Press |
|
2015-01-08 17:34 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2015-02-05 18:36 |
|
Typeset the Manuscript |
|
2015-04-08 19:18 |
|
Publish the Manuscript Online |
|
2015-04-20 15:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
|
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Growth inhibition and apoptosis induction by alternol in human pancreatic carcinoma cells
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Pei-Fang Cong, Ying-Chun Qu, Jie-Peng Chen, Li-Li Duan, Cheng-Jiang Lin, Xiao-Lin Zhu, Li-Ling Jesse and Mei-Xia Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of China |
81072899 |
| Natural Science Foundation of Liaoning Province |
2013021081 |
| Natural Science Foundation of Chongqing |
cstc2013jcyjA1587 |
|
| Corresponding Author |
Mei-Xia Zhang, PhD, Professor, Laboratory of Metabolic Disease Research and Drug Development, China Medical University, 77 Puhe Road, Shenyang 110001, Liaoning Province, China. zhangmeixia@mail.cmu.edu.cn |
| Key Words |
Pancreatic cancer; Alternol; Chemotherapy; Cell cycle; Apoptosis |
| Core Tip |
Pancreatic cancer is an aggressive disease with a 5-year survival of less than 5%. Alternol has shown an anti-cancer activity against various types of cancer cells. The aim of this study was to investigate the effect of alternol on pancreatic cancer cells. We found that alternol inhibited the proliferation of the PANC-1 and BxPC3 cells. It has induced apoptosis, cell cycle arrest while increased mitochondrial membrane permeability. Alternol treatment has activated caspase 3, up-regulated p53 and p21 expression while down-regulated Bcl-2 expression. In summary, we concluded that alternol may provide an effective regimen for the treatment of pancreatic cancers. |
| Publish Date |
2015-04-20 15:10 |
| Citation |
Cong PF, Qu YC, Chen JP, Duan LL, Lin CJ, Zhu XL, Li-Ling J, Zhang MX. Growth inhibition and apoptosis induction by alternol in pancreatic carcinoma cells. World J Gastroenterol 2015; 21(15): 4526-4535 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i15/4526.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i15.4526 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
