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Articles Published Processes
4/20/2015 9:13:00 AM | Browse: 1298 | Download: 1586
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Received |
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2014-09-11 08:09 |
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Peer-Review Started |
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2014-09-11 09:39 |
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To Make the First Decision |
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2014-11-14 18:51 |
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Return for Revision |
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2014-11-19 16:56 |
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Revised |
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2014-11-26 02:27 |
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Second Decision |
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2015-01-04 16:00 |
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Accepted by Journal Editor-in-Chief |
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2015-01-05 10:54 |
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Accepted by Executive Editor-in-Chief |
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2015-01-12 14:34 |
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Articles in Press |
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2015-01-12 14:34 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-03 15:22 |
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Publish the Manuscript Online |
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2015-04-20 09:13 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Review |
| Article Title |
Type 1 diabetes: A predictable disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Kimber M Simmons and Aaron W Michels |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Institute of Diabetes and Digestive Kidney Diseases |
R01 DK032083 |
| National Institute of Diabetes and Digestive Kidney Diseases |
K08 DK095995 |
| Juvenile Diabetes Research Foundation |
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| Children’s Diabetes Foundation |
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| Brehm Coalition |
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| Corresponding Author |
Aaron W Michels, MD, Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Mail Stop A140, 1775 Aurora Court, Aurora, CO 80045,
United States. aaron.michels@ucdenver.edu
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| Key Words |
Autoimmunity; Autoantibodies; Diabetes prevention; Screening; Type 1 diabetes |
| Core Tip |
Type 1 diabetes (T1D), the immune mediated form of diabetes, is now a predictable disease with the measurement of islet autoantibodies. The presence of two or more antibodies defines preclinical disease as nearly everyone with multiple antibodies progresses to clinical diabetes. With improved platforms to measure islet autoantibodies, screening the general population is now a goal. Early identification of preclinical diabetes allows for less diabetic ketoacidosis, early initiation of insulin therapy, and the potential to delay or prevent diabetes onset. Clinical trials using safe and specific therapies to block disease specific immune cells are underway in T1D.
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| Publish Date |
2015-04-20 09:13 |
| Citation |
Simmons KM, Michels AW. Type 1 diabetes: A predictable disease. World J Diabetes 2015; 6(3): 380-390 |
| URL |
http://www.wjgnet.com/1948-9358/full/v6/i3/380.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v6.i3.380 |
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