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Articles Published Processes
5/1/2015 7:01:00 PM | Browse: 1065 | Download: 1499
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Received |
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2014-09-12 10:53 |
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Peer-Review Started |
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2014-09-13 09:18 |
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To Make the First Decision |
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2014-09-28 12:29 |
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Return for Revision |
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2014-10-06 22:26 |
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Revised |
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2014-12-16 00:00 |
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Second Decision |
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2015-01-14 09:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-01-20 16:36 |
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Articles in Press |
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2015-01-20 16:36 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-04-20 09:23 |
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Publish the Manuscript Online |
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2015-05-01 19:01 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
Progress and prospects of engineered sequence-specific DNA modulating technologies for the management of liver diseases
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Samantha A Nicholson, Buhle Moyo and Patrick B Arbuthnot |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| South African National Research Foundation (NRF) |
GUNs 81768 |
| South African National Research Foundation (NRF) |
81692 |
| South African National Research Foundation (NRF) |
68339 |
| South African National Research Foundation (NRF) |
85981 |
| South African National Research Foundation (NRF) |
77954 |
| Poliomyelitis Research Foundation |
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| Claude Leon Foundation (SAN) |
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| University of the Witwatersrand Research Council (BM) |
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| Medical Research Council |
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| Corresponding Author |
Patrick B Arbuthnot, Wits/SA MRC Antiviral Gene Therapy Research Unit, School of Pathology, Health Sciences Faculty, University of the Witwatersrand, 7 York Road, Parktown, Private Bag 3, Wits 2050, Johannesburg,
South Africa. patrick.arbuthnot@wits.ac.za
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| Key Words |
Gene therapy; Zinc fingers; Transcription activator-like effectors; Clustered regularly interspaced short palindromic repeats; Homing endonucleases; Liver diseases |
| Core Tip |
The treatment of liver diseases is varied and often complicated. Gene editing is being developed to treat a variety of chronic disorders and has exciting potential for curing hepatic diseases. Engineering of derivatives of zinc finger proteins, transcription activator-like effectors, homing endonucleases and clustered regularly interspaced palindromic repeats potentially enables sequence-specific gene editing. These DNA binding proteins may be used to alter genes permanently or to influence the epigenetic status of liver cells for therapeutic benefit.
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| Publish Date |
2015-05-01 19:01 |
| Citation |
Nicholson SA, Moyo B, Arbuthnot PB. Progress and prospects of engineered sequence-specific DNA modulating technologies for the management of liver diseases. World J Hepatol 2015; 7(6): 859-873 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i6/859.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i6.859 |
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