Publication Name	World Journal of Hepatology
Manuscript ID	13998
Country	Italy

Received	2014-09-12 08:18
Peer-Review Started	2014-09-13 10:29
To Make the First Decision	2014-09-28 12:29
Return for Revision	2014-10-06 22:01
Revised	2014-10-21 02:26
Second Decision	2015-02-04 11:56
Accepted by Journal Editor-in-Chief	2015-02-04 20:28
Accepted by Executive Editor-in-Chief	2015-02-11 15:24
Articles in Press	2015-02-11 15:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-04-29 09:22
Publish the Manuscript Online	2015-05-19 17:28

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease
Manuscript Source	Invited Manuscript
All Author List	Francesco Paolo Russo, Kryssia Rodríguez-Castro, Laura Scribano, Giorgia Gottardo, Veronica Vanin and Fabio Farinati
Funding Agency and Grant Number
Corresponding Author	Francesco Paolo Russo, MD, PhD, Gas­troenterology/Multiviseral Transplant Unit, Department of Surgery, Oncology and Gastroenterology, Padua University Hospital, Via Giustiniani 2, 35128 PD Padua, Italy. francescopaolo.russo@unipd.it
Key Words	Hepatocellular carcinoma; Nucleos(t)ide analogues; Liver fibrosis; Pegylated interferon; Cirrhosis
Core Tip	The goal of therapy for chronic hepatitis B is to improve quality of life and survival by preventing progression of the disease to cirrhosis, decompensation, end-stage liver disease, hepatocellular carcinoma and death. Current therapeutic options do not eradicate hepatitis B virus (HBV) infection, since HBV remains either integrated in the host genome or in the nuclei of hepatocytes as covalently closed circular DNA, a fact that may favour oncogenesis towards the development of hepatocellular carcinoma, and explains HBV reactivation. It is mandatory for clinicians to start viral suppression in patients with active chronic liver disease, particularly in patients who have already developed advanced hepatic disease.
Publish Date	2015-05-19 17:28
Citation	Russo FP, Rodríguez-Castro K, Scribano L, Gottardo G, Vanin V, Farinati F. Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease. World J Hepatol 2015; 7(8): 1097-1104
URL	http://www.wjgnet.com/1948-5182/full/v7/i8/1097.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i8.1097

Full Article (PDF)	WJH-7-1097.pdf
Full Article (Word)	WJH-7-1097.doc
Manuscript File	13998-Review.doc
Answering Reviewers	13998-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	13998-Conflict-of-interest statement.pdf
Copyright License Agreement	13998-Copyright assignment.pdf
Peer-review Report	13998-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	13998-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	13998-Scientific misconduct check.pdf
Scientific Editor Work List	13998-Scientific editor work list.pdf