Publication Name	World Journal of Experimental Medicine
Manuscript ID	14014
Country	Japan

Received	2014-09-13 15:40
Peer-Review Started	2014-09-13 20:15
First Decision by Editorial Office Director
Return for Revision	2014-10-06 19:49
Revised	2014-10-11 15:23
Publication Fee Transferred
Second Decision by Editor	2015-04-01 15:08
Second Decision by Editor-in-Chief	2015-04-04 23:04
Final Decision by Editorial Office Director	2015-08-31 15:08
Articles in Press	2015-08-31 15:08
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-11-17 10:15
Publish the Manuscript Online	2015-11-23 08:36

ISSN	2220-315x (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Rheumatology
Manuscript Type	Minireviews
Article Title	Disease control by regulation of P-glycoprotein on lymphocytes in patients with rheumatoid arthritis
Manuscript Source	Invited Manuscript
All Author List	Shizuyo Tsujimura and Yoshiya Tanaka
Funding Agency and Grant Number	Funding Agency Grant Number part by research Grants-In-Aid for Scientific Research by the Ministry of Health, Labor and Welfare of Japan Ministry of Education, Culture, Sports, Science and Technology of Japan University of Occupational and Environmental Health, Japan
Corresponding Author	Yoshiya Tanaka, MD, PhD, professor, the First Department of Internal Medicine, University of Occu­pational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu 807-8555, Japan. tanaka@med.uoeh-u.ac.jp
Key Words	Multidrug resistance 1 gene; P-glycoprotein; Lymphocytes; Disease activity; Rheumatoid arthritis
Core Tip	In patients with refractory rheumatoid arthritis (RA) and high disease activity, overexpression of P-glycoprotein (P-gp) on lymphocytes can cause resistance to anti-rheumatic drugs through efflux of intracellular drugs from these cells. Lymphocytes activated by various stimuli, including tumor necrosis factor-α in RA patients apparently acquire P-gp-mediated multidrug resistance against certain anti-rheumatic drugs, which are substrates of P-gp. The use of biological agents that reduce P-gp expression as well as P-gp antagonists can successfully reduce the efflux of drugs from lymphocytes, suggesting that they can be used to overcome drug-resistance and improve clinical outcome.
Publish Date	2015-11-23 08:36
Citation	Tsujimura S, Tanaka Y. Disease control by regulation of P-glycoprotein on lymphocytes in patients with rheumatoid arthritis. World J Exp Med 2015; 5(4): 225-231
URL	http://www.wjgnet.com/2220-315X/full/v5/i4/225.htm
DOI	http://dx.doi.org/10.5493/wjem.v5.i4.225

Full Article (PDF)	WJEM-5-225.pdf
Full Article (Word)	WJEM-5-225.doc
Manuscript File	14014-Review.doc
Answering Reviewers	14014-Answering reviewers.pdf
Audio Core Tip	14014-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	14014-Conflict-of-interest statement.pdf
Copyright License Agreement	14014-Copyright assignment.pdf
Peer-review Report	14014-Peer-review(s).pdf
Scientific Misconduct Check	14014-Scientific misconduct check.pdf
Scientific Editor Work List	14014-Scientific editor work list.pdf