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12/2/2015 11:38:00 AM | Browse: 425 | Download: 539
Publication Name World Journal of Experimental Medicine
Manuscript ID 14014
Country/Territory Japan
2014-09-13 15:40
Peer-Review Started
2014-09-13 20:15
To Make the First Decision
2014-09-28 12:29
Return for Revision
2014-10-06 19:49
2014-10-11 15:23
Second Decision
2015-04-01 15:08
Accepted by Journal Editor-in-Chief
2015-04-04 23:04
Accepted by Company Editor-in-Chief
2015-08-31 15:08
Articles in Press
2015-08-31 15:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-11-17 10:15
Publish the Manuscript Online
2015-11-23 08:36
ISSN 2220-315x (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Rheumatology
Manuscript Type Minireviews
Article Title Disease control by regulation of P-glycoprotein on lymphocytes in patients with rheumatoid arthritis
Manuscript Source Invited Manuscript
All Author List Shizuyo Tsujimura and Yoshiya Tanaka
Funding Agency and Grant Number
Funding Agency Grant Number
part by research Grants-In-Aid for Scientific Research by the Ministry of Health, Labor and Welfare of Japan
Ministry of Education, Culture, Sports, Science and Technology of Japan
University of Occupational and Environmental Health, Japan
Corresponding author Yoshiya Tanaka, MD, PhD, professor, the First Department of Internal Medicine, University of Occu­pational and Environmental Health, School of Medicine, 1-1 Iseigaoka, Yahata-nishi, Kitakyushu 807-8555, Japan. tanaka@med.uoeh-u.ac.jp
Keywords Multidrug resistance 1 gene; P-glycoprotein; Lymphocytes; Disease activity; Rheumatoid arthritis
Core Tip In patients with refractory rheumatoid arthritis (RA) and high disease activity, overexpression of P-glycoprotein (P-gp) on lymphocytes can cause resistance to anti-rheumatic drugs through efflux of intracellular drugs from these cells. Lymphocytes activated by various stimuli, including tumor necrosis factor-α in RA patients apparently acquire P-gp-mediated multidrug resistance against certain anti-rheumatic drugs, which are substrates of P-gp. The use of biological agents that reduce P-gp expression as well as P-gp antagonists can successfully reduce the efflux of drugs from lymphocytes, suggesting that they can be used to overcome drug-resistance and improve clinical outcome.
Publish Date 2015-11-23 08:36
Citation Tsujimura S, Tanaka Y. Disease control by regulation of P-glycoprotein on lymphocytes in patients with rheumatoid arthritis. World J Exp Med 2015; 5(4): 225-231
Url http://www.wjgnet.com/2220-315X/full/v5/i4/225.htm
DOI http://dx.doi.org/10.5493/wjem.v5.i4.225
Full Article (PDF) WJEM-5-225.pdf
Full Article (Word) WJEM-5-225.doc
Manuscript File 14014-Review.doc
Answering Reviewers 14014-Answering reviewers.pdf
Audio Core Tip 14014-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 14014-Conflict-of-interest statement.pdf
Copyright License Agreement 14014-Copyright assignment.pdf
Peer-review Report 14014-Peer-review(s).pdf
Scientific Misconduct Check 14014-Scientific misconduct check.pdf
Scientific Editor Work List 14014-Scientific editor work list.pdf