Publication Name	World Journal of Gastroenterology
Manuscript ID	14035
Country	China

Received	2014-09-16 10:07
Peer-Review Started	2014-09-19 09:57
To Make the First Decision	2014-10-29 15:06
Return for Revision	2014-11-05 08:43
Revised	2014-11-12 08:41
Second Decision	2015-01-10 12:34
Accepted by Journal Editor-in-Chief	2015-01-12 09:49
Accepted by Executive Editor-in-Chief	2015-01-16 18:05
Articles in Press	2015-01-16 18:18
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-02-06 11:54
Typeset the Manuscript	2015-04-10 09:09
Publish the Manuscript Online	2015-04-27 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Intestinal dendritic cells change in number in fulminant hepatic failure
Manuscript Source	Unsolicited Manuscript
All Author List	Xu Cao, Mei Liu, Peng Wang and Dong-Yan Liu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 30871158 National Natural Science Foundation of China 81170604 Outstanding Scientific Fund of Shengjing Hospital
Corresponding Author	Dong-Yan Liu, Professor, Research Center, Shengjing Hospital of China Medical University and Key Laboratory of Congenital Malformation Research, Ministry of Health, No. 36 Sanhao Street, Heping District, Shenyang 110004, Liaoning Province, China. dongyan.liu@aliyun.com
Key Words	Fulminant hepatic failure; Intestinal dendritic cells; MHC Ⅱ; CD3; AKT/Phosphorylated-AKT
Core Tip	In this study, we showed that the expression of CD11b/c, CD83, CD86, CD74 and CD3 in the fulminant hepatic failure (FHF) group [D-galactosamine (D-Galn) + lipopolysaccharide (LPS) group] was significantly higher compared with the normal saline (NS) group. Additionally, the phosphorylated-AKT protein expression in the FHF, LPS and D-Galn groups was higher than that in the NS group. This result showed that a large number of dendritic cells mature, express CD86, and activate MHC class Ⅱ molecular pathways to induce a T cell response in FHF. In addition, the AKT pathway in FHF was activated.
Publish Date	2015-04-27 16:22
Citation	Cao X, Liu M, Wang P, Liu DY. Intestinal dendritic cells change in number in fulminant hepatic failure. World J Gastroenterol 2015; 21(16): 4883-4893
URL	http://www.wjgnet.com/1007-9327/full/v21/i16/4883.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i16.4883

Full Article (PDF)	WJG-21-4883.pdf
Full Article (Word)	WJG-21-4883.doc
Manuscript File	14035-Review.doc
Answering Reviewers	14035-Answering reviewers.pdf
Copyright License Agreement	14035-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	14035-Language certificate.pdf
Peer-review Report	14035-Peer-review(s).pdf
Scientific Editor Work List	14035-Scientific editor work list.pdf