Publication Name	World Journal of Gastroenterology
Manuscript ID	1405
Country	China

Received	2012-12-07 16:09
Peer-Review Started	2012-12-10 11:57
To Make the First Decision	2012-12-28 17:33
Return for Revision	2012-12-28 20:50
Revised	2013-01-17 16:02
Second Decision	2013-02-28 18:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-01 06:23
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-04-25 18:41
Typeset the Manuscript	2013-05-17 20:38
Publish the Manuscript Online	2013-05-28 09:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biotechnology & Applied Microbiology
Manuscript Type	Autobiography
Article Title	Protective effects of two Lactobacillus plantarum strains in hyperlipidemic mice
Manuscript Source	Invited Manuscript
All Author List	Li-Xin Wang, Kai Liu, Da-Wei Gao and Ji-Kui Hao
Funding Agency and Grant Number	Funding Agency Grant Number Chinese Ministry of Education Doctor Degree grant 20101333120011 Hebei Province Natural Science Fund C2011203137 Hebei Province Natural Science Fund 11965152D Chinese Postdoctoral grant 480013
Corresponding Author	Dr. Da-Wei Gao, Department of Biological Engineering, College of Environmental and Chemical Engineering, Yanshan University, No. 438 Hebei Street, Qinhuangdao 066004, Hebei Province, China. dwgao@ysu.edu.cn
Key Words	Lactobacillus plantarum; Hypolipidemic; Nuclear factor erythroid 2-related factor 2; Metabolic syndrome; Hepatic steatosis; Cardiovascular disease
Core Tip	Protective effects of Lactobacillus plantarum (L. plantarum) CAI6 and L. plantarum SC4 strains on hyperlipidemic mice were found, including regulating lipid metabolism, alleviating hepatic steatosis and reducing cardiovascular disease (CVD) risk. The mechanism of intracorporal antioxidation of Lactobacillus strains may be related to stimulation of nuclear factor-erythroid 2-related factor 2 (Nrf2) expression. Hypolipidemic effect and Nrf2-induced antioxidative defense may contribute to the reduction of CVD risk. We suggest that food fermented by the strains be used as part of the diet to relieve lipid metabolism related metabolic syndrome and to reduce the risk of CVD.
Publish Date	2013-05-28 09:36
Citation	Wang LX, Liu K, Gao DW, Hao JK. Protective effects of two Lactobacillus plantarum strains in hyperlipidemic mice. World J Gastroenterol 2013; 19(20): 3150-3156
URL	http://www.wjgnet.com/1007-9327/full/v19/i20/3150.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i20.3150

Full Article (PDF)	WJG-19-3150.pdf
Manuscript File	1405-Review.doc
Answering Reviewers	1405-Answering reviewers.doc
Copyright License Agreement	1405-Copyright assignment.pdf
Peer-review Report	1405-Peer review(s).docx
Scientific Editor Work List	1405-Scientific editor work list.doc