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Articles Published Processes
6/29/2015 4:40:00 PM | Browse: 781 | Download: 1126
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Received |
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2014-09-21 08:53 |
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Peer-Review Started |
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2014-09-21 09:05 |
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To Make the First Decision |
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2014-10-14 17:04 |
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Return for Revision |
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2014-10-19 17:10 |
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Revised |
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2014-11-27 21:36 |
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Second Decision |
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2015-01-16 10:09 |
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Accepted by Journal Editor-in-Chief |
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2015-01-16 18:41 |
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Accepted by Executive Editor-in-Chief |
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2015-01-21 17:00 |
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Articles in Press |
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2015-01-21 17:29 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-04-02 15:46 |
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Typeset the Manuscript |
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2015-06-12 12:10 |
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Publish the Manuscript Online |
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2015-06-29 16:33 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Integrin αvβ6 sustains and promotes tumor invasive growth in colon cancer progression
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guang-Yun Yang, Sen Guo, Cong-Ying Dong, Xian-Qiang Wang, Bing-Yang Hu, Yang-Feng Liu, Yong-Wei Chen, Jun Niu and Jia-Hong Dong |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| China Postdoctoral Science Foundation |
20080441310 |
| China Postdoctoral Science Foundation |
201003781 |
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| Corresponding Author |
Guang-Yun Yang, Associate Chief Physician, Hepatobiliary Department, PLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100183, China. yangguangyun301@163.com |
| Key Words |
Colonic neoplasms; Integrin αvβ6; Matrix metalloproteinase-9; Invasive growth |
| Core Tip |
This study is designed to identify the mechanisms by which integrin αvβ6 sustains and promotes tumor invasive growth in colon cancer progression. Our results suggested that integrin αvβ6 sustains and promotes tumor invasive growth in tumor progression via a self-perpetuating mechanism. Integrin αvβ6-mediated matrix metalloproteinase-9 secretion facilitates pericellular matrix degradation at high cell density, which provides the basis of invasive growth. |
| Publish Date |
2015-06-29 16:33 |
| Citation |
Yang GY, Guo S, Dong CY, Wang XQ, Hu BY, Liu YF, Chen YW, Niu J, Dong JH. Integrin v6 sustains and promotes tumor invasive growth in colon cancer progression. World J Gastroenterol 2015; 21(24): 7457-7467 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i24/7457.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i24.7457 |
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