Publication Name	World Journal of Gastroenterology
Manuscript ID	14130
Country	China

Received	2014-09-21 08:55
Peer-Review Started	2014-09-21 09:02
To Make the First Decision	2014-10-14 17:04
Return for Revision	2014-10-19 14:56
Revised	2014-12-03 20:38
Second Decision	2015-01-19 08:26
Accepted by Journal Editor-in-Chief	2015-01-19 18:47
Accepted by Executive Editor-in-Chief	2015-01-21 17:00
Articles in Press	2015-01-21 17:29
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-04-15 11:29
Typeset the Manuscript	2015-05-22 15:47
Publish the Manuscript Online	2015-06-18 17:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Detection of superficial esophageal squamous cell neoplasia by chromoendoscopy-guided confocal laser endomicroscopy
Manuscript Source	Unsolicited Manuscript
All Author List	Jin Huang, Yun-Sheng Yang, Zhong-Sheng Lu, Shuang-Fang Wang, Jing Yang and Jing Yuan
Funding Agency and Grant Number
Corresponding Author	Yun-Sheng Yang, Professor, Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, No. 28 Fuxing Road, 100853 Beijing, China. huangjin034@163.com
Key Words	Superficial esophageal neoplasia; Squamous cell neoplasm; Confocal endomicroscopy; Endoscopic submucosal dissection; Chromoendoscopy
Core Tip	The aim of the present study was to determine the diagnostic potential of confocal laser endomicroscopy (CLE) combined with Lugol’s iodine chromoendoscopy in detecting superficial esophageal squamous cell neoplasia (ESCN). Lugol’s chromoendoscopy-guided CLE was performed in 52 enrolled patients. In the same patients, chromoendoscopy-guided biopsy was performed by another endoscopist. A comparison of the detection rates between the CLE finding and biopsy was performed. The sensitivity, specificity, negative predictive value and positive predictive value of chromoendoscopy-guided CLE were 95.7%, 90%, 81.8% and 97.8%, respectively. There was a statistically significant difference in the detection of dysplasia between chromoendoscopy-guided CLE and biopsy. Lugol’s chromoendoscopy-guided CLE is a real-time, non-invasive endoscopic diagnostic technology; the accuracy of the detection of superficial ESCN is equivalent to or may be superior to biopsy histology.
Publish Date	2015-06-18 17:32
Citation	Huang J, Yang YS, Lu ZS, Wang SF, Yang J, Yuan J. Detection of superficial esophageal squamous cell neoplasia by chromoendoscopy-guided confocal laser endomicroscopy. World J Gastroenterol 2015; 21(22): 6974-6981
URL	http://www.wjgnet.com/1007-9327/full/v21/i22/6974.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i22.6974

Full Article (PDF)	WJG-21-6974.pdf
Full Article (Word)	WJG-21-6974.doc
Manuscript File	14130-Review.doc
Answering Reviewers	14130-Answering reviewers.pdf
Copyright License Agreement	14130-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	14130-Language certificate.pdf
Peer-review Report	14130-Peer-review(s).pdf
Scientific Misconduct Check	14130-CrossCheck.jpg
Scientific Editor Work List	14130-Scientific editor work list.pdf