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Articles Published Processes
3/9/2015 3:58:00 PM | Browse: 911 | Download: 956
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Received |
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2014-09-21 08:49 |
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Peer-Review Started |
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2014-09-21 09:00 |
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To Make the First Decision |
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2014-10-14 17:04 |
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Return for Revision |
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2014-10-19 16:00 |
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Revised |
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Second Decision |
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2014-11-25 18:03 |
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Accepted by Journal Editor-in-Chief |
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2014-11-25 23:37 |
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Accepted by Company Editor-in-Chief |
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2014-12-08 16:15 |
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Articles in Press |
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2014-12-08 17:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2014-12-29 08:01 |
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Typeset the Manuscript |
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2015-02-26 16:17 |
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Publish the Manuscript Online |
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2015-03-09 15:58 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of bifidobacterium on defensin-5 expression in intestinal injury of preweaning rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Wang, Shu-Fen Yang, Li-Hong Ren, Xiu-Xiu Zhang and Shui-Lian Yu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation of Education Department of Heilongjiang Province |
11521124 |
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| Corresponding Author |
Wei Wang, MD, Department of Pediatrics, the Second Affiliated Hospital of Harbin Medical University, No. 246 Xuefu Road, Nangang District, Harbin 150086, Heilongjiang Province, China. wendywang_1972@126.com |
| Key Words |
Bifidobacterium; Lipopolysaccharide; Ileum; Myeloperoxidase; Defensin-5 |
| Core Tip |
This study investigated the serum and ileal contents of myeloperoxidase (MPO) and the expression of ileal Defensin-5 mRNA in the preweaning rats with lipopolysaccharide (LPS)-induced intestinal injury. Serum and ileal MPO contents in the model group (group E) were significantly higher than those in the control group (group C) (P < 0.05), which peaked at 12 h and 6 h, respectively. MPO contents in the treatment group (group T) were significantly lower than those in group E (P < 0.05). The expression of defensin-5 mRNA in group E was significantly up-regulated, peaked at 2 h, and then decreased gradually. The expression of defensin-5 mRNA in group T was significantly lower than that in group E (P < 0.05). Serum and ileal MPO contents and ileal expression of defensin-5 mRNA increased in preweaning rats with LPS-induced intestinal injury. Bifidobacterium protects the gut by inhibiting MPO activity, not by increasing defensin-5 secretion. |
| Publish Date |
2015-03-09 15:58 |
| Citation |
Wang W, Yang SF, Ren LH, Zhang XX, Yu SL. Effect of bifidobacterium on defensin-5 expression in intestinal injury of preweaning rats. World J Gastroenterol 2015; 21(9): 2638-2644 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i9/2638.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i9.2638 |
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