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Articles Published Processes
4/27/2015 4:29:00 PM | Browse: 1797 | Download: 2883
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Received |
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2014-09-23 09:38 |
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Peer-Review Started |
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2014-09-24 12:05 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-11-13 09:40 |
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Revised |
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2014-12-07 00:00 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-01-28 14:13 |
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Second Decision by Editor-in-Chief |
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2015-01-28 15:35 |
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Final Decision by Editorial Office Director |
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2015-01-30 15:34 |
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Articles in Press |
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2015-01-30 18:30 |
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Edit the Manuscript by Language Editor |
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2015-02-13 17:20 |
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Typeset the Manuscript |
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2015-04-09 10:28 |
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Publish the Manuscript Online |
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2015-04-27 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Lian Shi, Chu-Hsuan Liu, Li-Li Ding, Yu Zheng, Xiao-Yan Fei, Lu Lu, Xue-Ming Zhou, Jian-Ye Yuan and Jian-Qun Xie |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Innovation Program of the Shanghai Municipal Education Commission |
12YZ065 |
| National Natural Science Foundation of China |
81072786 |
| National Natural Science Foundation of China |
81473630 |
| National Natural Science Foundation of China |
81202665 |
| Longhua Medical Project |
D-09 |
| High level Project of the University of Educational Commission of Shanghai, China |
2008GSP19 |
| Shanghai Leading Academic Discipline Project |
J50305 |
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| Corresponding Author |
Jian-Ye Yuan, Associate Professor, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 530 Lingling Road, Xuhui District, Shanghai 200032, China. yuanjianye@hotmail.com |
| Key Words |
Shugan decoction; Visceral hyperalgesia; Serotonin; Transient receptor potential; Protease-activated receptor; Serotonin transporter; Calcitonin-gene-related peptide; Tumor necrosis factor-a |
| Core Tip |
The present study demonstrated that Shugan decoction alleviated visceral hyperalgesia and attenuated colon motility in a rat model of irritable bowel syndrome, partly by regulating the expression of transient receptor potential (TRP) vanilloid 1, TRP vanilloid 4, TRP ankyrin-1 and protease-activated receptor 2, serotonin, chromogranin A and serotonin transporter, and reducing the levels of calcitonin-gene-related peptide and tumor necrosis factor-a. |
| Publish Date |
2015-04-27 16:22 |
| Citation |
Shi HL, Liu CH, Ding LL, Zheng Y, Fei XY, Lu L, Zhou XM, Yuan JY, Xie JQ. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol 2015; 21(16): 4852-4863
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| URL |
http://www.wjgnet.com/1007-9327/full/v21/i16/4852.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i16.4852 |
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