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4/27/2015 4:29:00 PM | Browse: 776 | Download: 862
Publication Name World Journal of Gastroenterology
Manuscript ID 14156
Country/Territory China
2014-09-23 09:38
Peer-Review Started
2014-09-24 12:05
To Make the First Decision
2014-10-29 14:21
Return for Revision
2014-11-13 09:40
2014-12-07 00:00
Second Decision
2015-01-28 14:13
Accepted by Journal Editor-in-Chief
2015-01-28 15:35
Accepted by Company Editor-in-Chief
2015-01-30 15:34
Articles in Press
2015-01-30 18:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-02-13 17:20
Typeset the Manuscript
2015-04-09 10:28
Publish the Manuscript Online
2015-04-27 16:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction
Manuscript Source Unsolicited Manuscript
All Author List Hai-Lian Shi, Chu-Hsuan Liu, Li-Li Ding, Yu Zheng, Xiao-Yan Fei, Lu Lu, Xue-Ming Zhou, Jian-Ye Yuan and Jian-Qun Xie
Funding Agency and Grant Number
Funding Agency Grant Number
Innovation Program of the Shanghai Municipal Education Commission 12YZ065
National Natural Science Foundation of China 81072786
National Natural Science Foundation of China 81473630
National Natural Science Foundation of China 81202665
Longhua Medical Project D-09
High level Project of the University of Educational Commission of Shanghai, China 2008GSP19
Shanghai Leading Academic Discipline Project J50305
Corresponding Author Jian-Ye Yuan, Associate Professor, Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, 530 Lingling Road, Xuhui District, Shanghai 200032, China. yuanjianye@hotmail.com
Key Words Shugan decoction; Visceral hyperalgesia; Serotonin; Transient receptor potential; Protease-activated receptor; Serotonin transporter; Calcitonin-gene-related peptide; Tumor necrosis factor-a
Core Tip The present study demonstrated that Shugan decoction alleviated visceral hyperalgesia and attenuated colon motility in a rat model of irritable bowel syndrome, partly by regulating the expression of transient receptor potential (TRP) vanilloid 1, TRP vanilloid 4, TRP ankyrin-1 and protease-activated receptor 2, serotonin, chromogranin A and serotonin transporter, and reducing the levels of calcitonin-gene-related peptide and tumor necrosis factor-a.
Publish Date 2015-04-27 16:22
Citation Shi HL, Liu CH, Ding LL, Zheng Y, Fei XY, Lu L, Zhou XM, Yuan JY, Xie JQ. Alterations in serotonin, transient receptor potential channels and protease-activated receptors in rats with irritable bowel syndrome attenuated by Shugan decoction. World J Gastroenterol 2015; 21(16): 4852-4863
Url http://www.wjgnet.com/1007-9327/full/v21/i16/4852.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i16.4852
Full Article (PDF) WJG-21-4852.pdf
Full Article (Word) WJG-21-4852.doc
Manuscript File 14156-Review.doc
Answering Reviewers 14156-Answering reviewers.pdf
Biostatistics Review Certificate 14156-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 14156-Conflict-of-interest statement.pdf
Copyright License Agreement 14156-Copyright assignment.pdf
Data Sharing Statement 14156-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 14156-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 14156-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 14156-Language certificate.PDF
Peer-review Report 14156-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 14156-Journal Editor-in-Chief's Review Report.pdf
Scientific Misconduct Check 14156-CrossCheck.jpg
Scientific Editor Work List 14156-Scientific editor work list.pdf