Publication Name	World Journal of Gastroenterology
Manuscript ID	1416
Country	China

Received	2012-12-09 12:53
Peer-Review Started	2012-12-10 16:22
To Make the First Decision	2013-04-16 09:13
Return for Revision	2013-04-18 10:29
Revised	2013-05-13 19:41
Second Decision	2013-06-08 14:09
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-06-10 04:05
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-24 14:42
Publish the Manuscript Online	2013-07-06 17:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells
Manuscript Source	Invited Manuscript
All Author List	Shi-Hai Xia, Xiao-Hui Xiang, Kai Chen and Wei Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81173393 Natural Science Foundation of Tianjin City 12YFJZJC00800 Scientific Research Foundation for PhD WYB201010 (to Xia SH) Innovation Team Program (WHTD201310) from the Logistics University of the Chinese People’s Armed Police Force
Corresponding Author	Shi-Hai Xia, MD, PhD, Department of Hepatopancreatobiliary and Splenic Medicine, Affiliated Hospital of the Logistics University of the Chinese People's Armed Police Force, 220 Chenglin Road, Hedong District, Tianjin 300162, China. xshhcx@sina.com
Key Words	BN52021; Platelet-activating factor receptor; Signaling pathway; Inflammation; Pancreatitis
Core Tip	Microcirculatory disorder is considered to be one of the possible mechanisms of pathogenesis of severe acute pancreatitis (SAP). Platelet-activating factor (PAF) is known to mediate microcirculatory disturbance and inflammation. Although BN52021, a PAF receptor antagonist, has demonstrated significant treatment effects on SAP, its mechanism has not been elucidated in detail. In this study, we examined the signaling molecules of the PAF receptor pathway to evaluate whether BN52021 has any influence on the inflammatory effects induced by lipopolysaccharide in MS1 cells, hoping to elucidate the mechanism underlying microcirculatory disturbances in the pathogenesis of SAP in vitro.
Publish Date	2013-07-06 17:46
Citation	Xia SH, Xiang XH, Chen K, Xu W. Roles of BN52021 in platelet-activating factor pathway in inflammatory MS1 cells. World J Gastroenterol 2013; 19(25): 3969-3979
URL	http://www.wjgnet.com/1007-9327/full/v19/i25/3969.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i25.3969

Full Article (PDF)	WJG-19-3969.pdf
Manuscript File	1416-Review.doc
Answering Reviewers	1416-Answering reviewers.doc
Copyright License Agreement	1416-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	1416-Language certificate.pdf
Peer-review Report	1416-Peer review(s).pdf
Scientific Editor Work List	1416-Scientific editor work list.doc