Publication Name	World Journal of Respirology
Manuscript ID	14208
Country	Japan

Received	2014-09-24 18:21
Peer-Review Started	2014-09-26 10:10
To Make the First Decision	2014-11-14 19:37
Return for Revision	2014-11-19 16:38
Revised	2014-11-25 13:55
Second Decision	2014-12-15 08:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-12-19 17:49
Articles in Press	2014-12-19 17:49
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-03-10 15:29
Publish the Manuscript Online	2015-03-23 14:01

ISSN	2218-6255 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Respiratory System
Manuscript Type	Review
Article Title	Role of p53 in lung tissue remodeling
Manuscript Source	Invited Manuscript
All Author List	Shiro Mizuno, Harm Jan Bogaard, Takeshi Ishizaki and Hirohisa Toga
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan 24591144
Corresponding Author	Shiro Mizuno, MD, PhD, Associate Professor, Division of Respiratory Medicine, Kanazawa Medical University, 1-1 Daigaku Uchinada-cho Kahoku-gun, Ishikawa 920-0265, Japan. shirotan@kanazawa-med.ac.jp
Key Words	Chronic obstructive pulmonary disease; Pulmonary hypertension; Asthma; p21; Mouse double minute 2 homolog
Core Tip	The activated p53 protein and its associated pathway play a pivotal role in tissue remodeling in chronic obstructive pulmonary disease, asthma and pulmonary hypertension. p53 protein regulates numerous genes and proteins associated with cell cycle arrest and apoptosis. In response to oxidative stress or hypoxia, p53 can become stabilized and activate signal transduction towards lung tissue remodeling and functional loss.
Publish Date	2015-03-23 14:01
Citation	Mizuno S, Bogaard HJ, Ishizaki T, Toga H. Role of p53 in lung tissue remodeling. World J Respirol 2015; 5(1): 40-46
URL	http://www.wjgnet.com/2218-6255/full/v5/i1/40.htm
DOI	http://dx.doi.org/10.5320/wjr.v5.i1.40

Full Article (PDF)	WJR-5-40.pdf
Full Article (Word)	WJR-5-40.doc
Manuscript File	14208-Review.doc
Answering Reviewers	14208-Answering reviewers.pdf
Conflict-of-Interest Disclosure Form	14208-Conflict-of-interest statement.pdf
Copyright License Agreement	14208-Copyright assignment.pdf
Peer-review Report	14208-Peer review(s).pdf
Scientific Misconduct Check	14208-CrossCheck.jpg
Scientific Editor Work List	14208-Scientific editor work list.pdf