Publication Name	World Journal of Respirology
Manuscript ID	14227
Country	Portugal

Received	2014-09-25 09:30
Peer-Review Started	2014-09-26 08:15
To Make the First Decision	2014-12-17 11:27
Return for Revision	2014-12-19 10:26
Revised	2015-03-09 23:50
Second Decision	2015-04-20 11:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-04-30 11:24
Articles in Press	2015-04-30 11:24
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-08 08:29
Typeset the Manuscript	2015-07-10 09:54
Publish the Manuscript Online	2015-08-04 12:43

ISSN	2218-6255 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Case Report
Article Title	Myasthenia gravis as a form of clinical presentation of thymic carcinoma
Manuscript Source	Invited Manuscript
All Author List	Joana Espiga de Macedo, Sílvia Lopes, Helena Gouveia, Sofia Oliveira, João Cunha, Ana Luísa Faria, Sónia Rego, Albino Oliveira, Luís Krug and Emílio Macias Bravo
Funding Agency and Grant Number
Corresponding Author	Joana Espiga de Macedo, MD, Department of Medical Oncology of Centro Hospitalar de Entre o Douro e Vouga, Rua Dr. Cândido de Pinho, 4520-211 Santa Maria Da Feira, Portugal. joanamacedo@hotmail.com
Key Words	Myasthenia gravis; Thymic carcinoma; Multidisciplinary approach; Clinical-molecular signature; Prognosis
Core Tip	We report a rare form of clinical presentation of a thymic carcinoma in which the diagnosis of myasthenia gravis was the cornerstone of the dia?gnosis of cancer. Surgery is considered the salvage treatment when possible. Radiotherapy is a second choice of salvage treatment, when possible depending on its localization and relation to nearby structures such as vascular structures. The prognosis is very reserved, when neither surgery nor radiotherapy can be accomplished. Having an unfavorable molecular signature, less than 10% of thymic carcinomas have c-kit mutations, and clinical outcome of these patients is detrimental.
Publish Date	2015-08-04 12:43
Citation	de Macedo JE, Lopes S, Gouveia H, Oliveira S, Cunha J, Faria AL, Rego S, Oliveira A, Krug L, Bravo EM. Myasthenia gravis as a form of clinical presentation of thymic carcinoma. World J Respirol 2015; 5(2): 176-179
URL	http://www.wjgnet.com/2218-6255/full/v5/i2/176.htm
DOI	http://dx.doi.org/10.5320/wjr.v5.i2.176

Full Article (PDF)	WJR-5-176.pdf
Full Article (Word)	WJR-5-176.doc
Manuscript File	14227-Review.docx
Answering Reviewers	14227-Answering reviewers.pdf
Audio Core Tip	14227-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	14227-Conflict-of-interest statement.pdf
Copyright License Agreement	14227-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	14227-Institutional review board statement.pdf
Peer-review Report	14227-Peer-review(s) .pdf
Scientific Misconduct Check	14227-Scientific misconduct check.pdf
Scientific Editor Work List	14227-Scientific editor work list.pdf