Publication Name	World Journal of Gastroenterology
Manuscript ID	14246
Country	Italy

Received	2014-09-26 08:52
Peer-Review Started	2014-09-29 09:30
To Make the First Decision	2014-12-02 09:25
Return for Revision	2014-12-03 10:49
Revised	2014-12-20 07:10
Second Decision	2015-03-11 15:22
Accepted by Journal Editor-in-Chief	2015-03-11 15:33
Accepted by Executive Editor-in-Chief	2015-03-19 17:05
Articles in Press	2015-03-19 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-05 17:22
Publish the Manuscript Online	2015-05-20 17:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Prospective Study
Article Title	Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients
Manuscript Source	Invited Manuscript
All Author List	Girolamo Ranieri, Michele Ammendola, Ilaria Marech, Annamaria Laterza, Ines Abbate, Caroline Oakley, Angelo Vacca, Rosario Sacco and Cosmo Damiano Gadaleta
Funding Agency and Grant Number	Funding Agency Grant Number Alleanza Contro il Cancro” project), the Italian National Health Institute and the Italian Ministry of Health(partly).
Corresponding Author	Girolamo Ranieri, MD, Diagnostic and Interventional Radiology Unit with Integrated Section of Translational Medical Oncology, National Cancer Research Centre, Istituto Tumori “Giovanni Paolo II”, Via Orazio Flacco 65, 70124 Bari, Italy. giroran@tiscalinet.it
Key Words	Serum levels; Trypatse; Vascular Endothelial Growth Factor; Hepatocellular Cancer; Chemoembolization
Core Tip	Experimental data suggest that vascular endothelial growth factor (VEGF) and tryptase play a role in tumour angiogenesis. This study aims to assess VEGF and tryptase serum concentrations from 71 hepatocellular cancer patients before and after hepatic trans-arterial chemoembolization (TACE) by mean of enzyme-linked immuno-absorbent assay and fluoro-enzyme immunoassay methods respectively. Here, we demonstrated higher serum VEGF levels and lower tryptase levels following TACE as compared to pre-TACE levels. We suggest that changes of VEGF and tryptase levels may be biomarkers of response to therapy. In this context tryptase and VEGF receptor axis inhibitors may be evaluated as adjuvant therapies.
Publish Date	2015-05-20 17:01
Citation	Ranieri G, Ammendola M, Marech I, Laterza A, Abbate I, Oakley C, Vacca A, Sacco R, Gadaleta CD. Vascular endothelial growth factor and tryptase changes after chemoembolization in hepatocarcinoma patients. World J Gastroenterol 2015; 21(19): 6018-6025
URL	http://www.wjgnet.com/1007-9327/full/v21/i19/6018.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i19.6018

Full Article (PDF)	WJG-21-6018.pdf
Full Article (Word)	WJG-21-6018.doc
Manuscript File	14246-Review.doc
Answering Reviewers	14246-Answering reviewers.pdf
Copyright License Agreement	14246-Copyright assignment.pdf
Peer-review Report	14246-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14246-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	14246-Scientific misconduct check.pdf
Scientific Editor Work List	14246-Scientific editor work list.pdf