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8/17/2015 11:14:00 AM | Browse: 410 | Download: 622
Publication Name World Journal of Gastroenterology
Manuscript ID 14258
Country of Manuscript Source China
Received
2014-09-27 12:51
Peer-Review Started
2014-09-29 10:26
To Make the First Decision
2014-12-02 09:25
Return for Revision
2014-12-03 14:09
Revised
2015-01-08 00:30
Second Decision
2015-05-13 07:29
Accepted by Journal Editor-in-Chief
2015-05-14 02:09
Accepted by Company Editor-in-Chief
2015-06-10 16:11
Articles in Press
2015-06-10 16:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-07-29 17:47
Publish the Manuscript Online
2015-08-17 11:15
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Basic Study
Article Title Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells
Manuscript Source Unsolicited Manuscript
All Author List Yan-Ling Chen, Jun-Jiao Song, Xiao-Chun Chen, Wei Xu, Qiang Zhi, Yun-Peng Liu, Hong-Zhi Xu, Jin-Shui Pan, Jian-Lin Ren and Bayasi Guleng
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81370505
National Natural Science Foundation of China 81370591
National Natural Science Foundation of China 81225025
National Natural Science Foundation of China 81100285
National Natural Science Foundation of China 91229201
National High-tech R&D Program of China (863 Program) 2012AA02A201
National Basic Research Program of China(973 Program) 2013CB944903
Corresponding author Dr. Bayasi Guleng, Department of Gastroenterology, Zhongshan Hospital affiliated with Xiamen University, No. 201 Hubin South Road, Xiamen 361004, Fujian Province, China. bayasi8@gmail.com
Keywords Pyruvate kinase; Migration; Epidermal growth factor/EGFR signaling pathway; Transforming growth factor beta signaling pathway; Hepatocellular carcinoma
Core Tip The present study is to explore the effects of pyruvate kinase M2 (PKM2) on motility of human hepatocellular carcinoma cells. Here, our results revealed that silenced PKM2 activated the epidermal growth factor (EGF)/EGFR and transforming growth factor beta (TGFβ)/TGFR signaling pathways, in addition, up-regulate the expression of downstream targets, and this is the first research to connect PKM2 with the vital EGF and TGFβ pathways in hepatocellular carcinoma cell motility.
Publish Date 2015-08-17 11:15
Citation Chen YL, Song JJ, Chen XC, Xu W, Zhi Q, Liu YP, Xu HZ, Pan JS, Ren JL, Guleng B. Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells. World J Gastroenterol 2015; 21(30): 9093-9102
Url http://www.wjgnet.com/1007-9327/full/v21/i30/9093.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i30.9093
Full Article (PDF) WJG-21-9093.pdf
Full Article (Word) WJG-21-9093.doc
Manuscript File 14258-Review.doc
Answering Reviewers 14258-Answering reviewers.pdf
Audio Core Tip 14258-Audio core tip.WAV
Copyright License Agreement 14258-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 14258-Language certificate.pdf
Peer-review Report 14258-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 14258-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 14258-Scientific misconduct check.pdf
Scientific Editor Work List 14258-Scientific editor work list.pdf