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Articles Published Processes
8/17/2015 11:14:00 AM | Browse: 1334 | Download: 1742
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Received |
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2014-09-27 12:51 |
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Peer-Review Started |
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2014-09-29 10:26 |
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To Make the First Decision |
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2014-12-02 09:25 |
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Return for Revision |
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2014-12-03 14:09 |
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Revised |
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2015-01-08 00:30 |
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Second Decision |
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2015-05-13 07:29 |
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Accepted by Journal Editor-in-Chief |
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2015-05-14 02:09 |
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Accepted by Executive Editor-in-Chief |
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2015-06-10 16:11 |
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Articles in Press |
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2015-06-10 16:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-07-29 17:47 |
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Publish the Manuscript Online |
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2015-08-17 11:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan-Ling Chen, Jun-Jiao Song, Xiao-Chun Chen, Wei Xu, Qiang Zhi, Yun-Peng Liu, Hong-Zhi Xu, Jin-Shui Pan, Jian-Lin Ren and Bayasi Guleng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81370505 |
| National Natural Science Foundation of China |
81370591 |
| National Natural Science Foundation of China |
81225025 |
| National Natural Science Foundation of China |
81100285 |
| National Natural Science Foundation of China |
91229201 |
| National High-tech R&D Program of China (863 Program) |
2012AA02A201 |
| National Basic Research Program of China（973 Program） |
2013CB944903 |
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| Corresponding Author |
Dr. Bayasi Guleng, Department of Gastroenterology, Zhongshan Hospital affiliated with Xiamen University, No. 201 Hubin South Road, Xiamen 361004, Fujian Province, China. bayasi8@gmail.com |
| Key Words |
Pyruvate kinase; Migration; Epidermal growth factor/EGFR signaling pathway; Transforming growth factor beta signaling pathway; Hepatocellular carcinoma |
| Core Tip |
The present study is to explore the effects of pyruvate kinase M2 (PKM2) on motility of human hepatocellular carcinoma cells. Here, our results revealed that silenced PKM2 activated the epidermal growth factor (EGF)/EGFR and transforming growth factor beta (TGFβ)/TGFR signaling pathways, in addition, up-regulate the expression of downstream targets, and this is the first research to connect PKM2 with the vital EGF and TGFβ pathways in hepatocellular carcinoma cell motility. |
| Publish Date |
2015-08-17 11:15 |
| Citation |
Chen YL, Song JJ, Chen XC, Xu W, Zhi Q, Liu YP, Xu HZ, Pan JS, Ren JL, Guleng B. Mechanisms of pyruvate kinase M2 isoform inhibits cell motility in hepatocellular carcinoma cells. World J Gastroenterol 2015; 21(30): 9093-9102 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i30/9093.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i30.9093 |
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