Publication Name	World Journal of Gastroenterology
Manuscript ID	14304
Country	China

Received	2014-09-28 08:30
Peer-Review Started	2014-09-29 18:05
To Make the First Decision	2014-10-29 14:58
Return for Revision	2014-10-31 17:45
Revised	2014-11-22 00:36
Second Decision	2015-01-27 12:21
Accepted by Journal Editor-in-Chief	2015-01-28 11:36
Accepted by Executive Editor-in-Chief	2015-01-30 15:36
Articles in Press	2015-01-30 18:30
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-03-31 09:46
Typeset the Manuscript	2015-05-17 17:23
Publish the Manuscript Online	2015-05-30 13:32

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways
Manuscript Source	Unsolicited Manuscript
All Author List	Guang-Ming Huang, Yu Sun, Xin Ge, Xin Wan and Chun-Bo Li
Funding Agency and Grant Number
Corresponding Author	Xin Ge, MD, Department of General Surgery, Heilongjiang Provincial Hospital, 82 Zhongshan Road, Harbin 150036, Heilongjiang Province, China. gexin628@163.com
Key Words	Apoptosis; Death receptor pathway; Flow cytometry; Gambogic acid; Hoechst 33342; HT-29 cells; Mitochondrial pathway; MTT; Terminal deoxynucleotidyl transferase dUTP nick end labeling
Core Tip	This study evaluated the effects of gambogic acid on colon cancer cells. Treatment of a human colon cancer cell line with gambogic acid inhibited proliferation via induction of apoptosis. Moreover, the growth of colon cancer cell xenograft tumors in mice was reduced by injections of gambogic acid. These anti-cancer effects were likely mediated through death receptor and mitochondrial pathways.
Publish Date	2015-05-30 13:32
Citation	Huang GM, Sun Y, Ge X, Wan X, Li CB. Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways. World J Gastroenterol 2015; 21(20): 6194-6205
URL	http://www.wjgnet.com/1007-9327/full/v21/i20/6194.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i20.6194

Full Article (PDF)	WJG-21-6194.pdf
Full Article (Word)	WJG-21-6194.doc
Manuscript File	14304-Review.docx
Answering Reviewers	14304-Answering reviewers.pdf
Biostatistics Review Certificate	14304-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	14304-Conflict-of-interest statement.pdf
Copyright License Agreement	14304-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	14304-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	14304-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	14304-Language certificate.pdf
Peer-review Report	14304-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	14304-Journal Editor-in-Chief's Review Report.pdf
Scientific Misconduct Check	14304-CrossCheck.jpg
Scientific Editor Work List	14304-Scientific editor work list.pdf