Publication Name	World Journal of Psychiatry
Manuscript ID	14318
Country	Italy

Received	2014-09-29 11:17
Peer-Review Started	2014-09-29 21:42
To Make the First Decision	2014-10-28 14:18
Return for Revision	2014-11-03 14:34
Revised	2014-11-12 18:05
Second Decision	2014-11-28 15:05
Accepted by Journal Editor-in-Chief	2014-11-30 01:24
Accepted by Executive Editor-in-Chief	2014-12-10 17:39
Articles in Press	2014-12-10 17:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-12-16 19:53
Publish the Manuscript Online	2014-12-23 15:50

ISSN	2220-3206 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Psychiatry
Manuscript Type	Review
Article Title	Memantine: New prospective in bipolar disorder treatment
Manuscript Source	Invited Manuscript
All Author List	Giulia Serra, Francesca Demontis, Francesca Serra, Lavinia De Chiara, Andrea Spoto, Paolo Girardi, Giulio Vidotto and Gino Serra
Funding Agency and Grant Number	Funding Agency Grant Number Research Fellowship from the Sapienza Foundation, Rome to Giulia S(In part) Fondazione Banco di Sardegna, Italy to Gino S
Corresponding Author	Dr. Gino Serra, MD, Department of Biomedical Science, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy. dsfserra@uniss.it
Key Words	Memantine; Bipolar disorder; Depression; Mood stabilizer; Manic symptoms
Core Tip	Memantine, blocks the development of the supersensitivity of dopamine receptors caused by antidepressants and the ensuing desensitization associated with the depressive like behavior. On the basis of these observations we have suggested the use of memantine in the treatment of mania and in the prophylaxis of bipolar disorders. To test this hypothesis we performed several naturalistic studies that showed an acute antimanic effect and a long-lasting and progressive mood-stabilizing action (at least 3 years), without clinically relevant side effects. To confirm the observations of our naturalistic trials we are now performing a randomized controlled clinical trial. Finally we described the studies reporting the efficacy of memantine in manic-like symptoms occurring in psychiatric disorders other than bipolar.
Publish Date	2014-12-23 15:50
Citation	Serra G, Demontis F, Serra F, De Chiara L, Spoto A, Girardi P, Vidotto G, Serra G. Memantine: New prospective in bipolar disorder treatment. World J Psychiatr 2014; 4(4): 80-90
URL	http://www.wjgnet.com/2220-3206/full/v4/i4/80.htm
DOI	http://dx.doi.org/10.5498/wjp.v4.i4.80

Full Article (PDF)	WJP-4-80.pdf
Full Article (Word)	WJP-4-80.doc
Manuscript File	14318-Review.doc
Answering Reviewers	14318-Answering reviewers.PDF
Conflict-of-Interest Disclosure Form	14318-Conflict-of-interest statement.pdf
Copyright License Agreement	14318-Copyright assignment.PDF
Non-Native Speakers of English Editing Certificate	14318-Language certificate.pdf
Peer-review Report	14318-Peer review(s).pdf
Scientific Misconduct Check	14318-CrossCheck.jpg
Scientific Editor Work List	14318-Scientific editor work list.pdf